Anti-SPTLC2 Antibody (CAB11716)
- SKU:
- CAB11716
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
| Antibody Name: | Anti-SPTLC2 Antibody |
| Antibody SKU: | CAB11716 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 423-562 of human SPTLC2 (NP_004854.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | BxPC-3, U-87MG, 293T, Mouse kidney, Mouse stomach |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 423-562 of human SPTLC2 (NP_004854.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MKCI MGQD GTSL GKEC VQQL AENT RYFR RRLK EMGF IIYG NEDS PVVP LMLY MPAK IGAF GREM LKRN IGVV VVGF PATP IIES RARF CLSA AHTK EILD TALK EIDE VGDL LQLK YSRH RLVP LLDR PFDE TTYE ETED |
| Gene ID: | 9517 |
| Uniprot: | O15270 |
| Cellular Location: | Endoplasmic reticulum membrane, Single-pass membrane protein |
| Calculated MW: | 62kDa |
| Observed MW: | 58kDa |
| Synonyms: | SPTLC2, HSN1C, LCB2, LCB2A, NSAN1C, SPT2, hLCB2a |
| Background: | This gene encodes a long chain base subunit of serine palmitoyltransferase. Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine. Mutations in this gene were identified in patients with hereditary sensory neuropathy type I. |
| NCBI Summary: | This gene encodes a long chain base subunit of serine palmitoyltransferase. Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine. Mutations in this gene were identified in patients with hereditary sensory neuropathy type I. [provided by RefSeq, Mar 2011] |
| UniProt Code: | O15270 |
| NCBI GenInfo Identifier: | 6685580 |
| NCBI Gene ID: | 9517 |
| NCBI Accession: | O15270.1 |
| UniProt Related Accession: | O15270 |
| Molecular Weight: | ~ 58kDa |
| NCBI Full Name: | Serine palmitoyltransferase 2 |
| NCBI Synonym Full Names: | serine palmitoyltransferase long chain base subunit 2 |
| NCBI Official Symbol: | SPTLC2 |
| NCBI Official Synonym Symbols: | LCB2; SPT2; HSN1C; LCB2A; NSAN1C; hLCB2a |
| NCBI Protein Information: | serine palmitoyltransferase 2 |
| UniProt Protein Name: | Serine palmitoyltransferase 2 |
| UniProt Synonym Protein Names: | Long chain base biosynthesis protein 2; LCB 2; Long chain base biosynthesis protein 2a; LCB2a; Serine-palmitoyl-CoA transferase 2; SPT 2 |
| Protein Family: | Serine palmitoyltransferase |
| UniProt Gene Name: | SPTLC2 |
| UniProt Entry Name: | SPTC2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SPTLC2 Antibody (CAB11716) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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