Anti-SPOP Antibody (CAB7621)
- SKU:
- CAB7621
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
| Antibody Name: | Anti-SPOP Antibody |
| Antibody SKU: | CAB7621 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of mouse SPOP (NP_079563.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | BT-474, Mouse pancreas |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of mouse SPOP (NP_079563.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSRV PSPP PPAE MSSG PVAE SWCY TQIK VVKF SYMW TINN FSFC REEM GEVI KSST FSSG ANDK LKWC LRVN PKGL DEES KDYL SLYL LLVS CPKS EVRA KFKF SILN AKGE ETKA MESQ RAYR FVQG KDWG FKKF IRRD FLLD EANG LLPD DKLT LFCE VSVV QDSV NISG QNTM NMVK VPEC RLAD ELGG LWEN SRFT DCCL CVAG QEFQ AHKA ILAA RSPV FSAM FEHE MEES KKNR VEIN DVEP EVFK EMMC FIYT GKAP NLDK MA |
| Gene ID: | 20747 |
| Uniprot: | |
| Cellular Location: | Nucleus, Nucleus speckle |
| Calculated MW: | 42kDa |
| Observed MW: | 42kDa |
| Synonyms: | SPOP, BTBD32, TEF2 |
| Background: | This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. |
 | Western blot analysis of extracts of various cell lines, using SPOP antibody (CAB7621) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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