| Background: | This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. |
| UniProt Protein Function: | SPOP: Inhibits IPF1/PDX1 transactivation of established target promoters, such as insulin, may be by recruiting a repressor complex. In complex with CUL3, involved in ubiquitination of BMI1, H2AFY and DAXX, and probably also in ubiquitination and proteasomal degradation of Gli2 or Gli3. Belongs to the Tdpoz family. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 17q21.33 Cellular Component: nucleoplasm; nucleus Molecular Function:protein binding; ubiquitin protein ligase binding Biological Process: proteasomal ubiquitin-dependent protein catabolic process |
| NCBI Summary: | This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O43791 |
| NCBI GenInfo Identifier: | 8134708 |
| NCBI Gene ID: | 8405 |
| NCBI Accession: | O43791.1 |
| UniProt Secondary Accession: | O43791,Q53HJ1, B2R6S3, D3DTW7, |
| UniProt Related Accession: | O43791 |
| Molecular Weight: | 42,132 Da |
| NCBI Full Name: | Speckle-type POZ protein |
| NCBI Synonym Full Names: | speckle type BTB/POZ protein |
| NCBI Official Symbol: | SPOP |
| NCBI Official Synonym Symbols: | TEF2; BTBD32 |
| NCBI Protein Information: | speckle-type POZ protein |
| UniProt Protein Name: | Speckle-type POZ protein |
| UniProt Synonym Protein Names: | HIB homolog 1; Roadkill homolog 1 |
| Protein Family: | Speckle-type POZ protein |
| UniProt Gene Name: | SPOP |
| UniProt Entry Name: | SPOP_HUMAN |
