Anti-SPOCK3 Antibody (CAB12849)

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SKU:
CAB12849
Product type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
Frequently bought together:

Description

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Antibody Name:Anti-SPOCK3 Antibody
Antibody SKU:CAB12849
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 180-380 of human SPOCK3 (NP_001035249.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse brain, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 180-380 of human SPOCK3 (NP_001035249.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:CPCP SDKP TSTS RNVK RACS DLEF REVA NRLR DWFK ALHE SGSQ NKKT KTLL RPER SRFD TSIL PICK DSLG WMFN RLDT NYDL LLDQ SELR SIYL DKNE QCTK AFFN SCDT YKDS LISN NEWC YCFQ RQQD PPCQ TELS NIQK RQGV KKLL GQYI PLCD EDGY YKPT QCHG SVGQ CWCV DRYG NEVM GSRI NGVA DCAI D
Gene ID:50859
Uniprot:Q9BQ16
Cellular Location:Secreted, extracellular matrix, extracellular space
Calculated MW:35kDa/36kDa/38kDa/44kDa/49kDa
Observed MW:49kDa
Synonyms:SPOCK3, HSAJ1454, TES-3, TICN3
Background:This gene encodes a member of a novel family of calcium-binding proteoglycan proteins that contain thyroglobulin type-1 and Kazal-like domains. The encoded protein and may play a role in adult T-cell leukemia by inhibiting the activity of membrane-type matrix metalloproteinases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
UniProt Protein Function:SPOCK3: May participate in diverse steps of neurogenesis. Inhibits the processing of pro-matrix metalloproteinase 2 (MMP-2) by MT1-MMP and MT3-MMP. May interfere with tumor invasion. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 4q32.3

Molecular Function:metalloendopeptidase inhibitor activity

NCBI Summary:This gene encodes a member of a novel family of calcium-binding proteoglycan proteins that contain thyroglobulin type-1 and Kazal-like domains. The encoded protein and may play a role in adult T-cell leukemia by inhibiting the activity of membrane-type matrix metalloproteinases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
UniProt Code:Q9BQ16
NCBI GenInfo Identifier:67473703
NCBI Gene ID:50859
NCBI Accession:Q9BQ16.2
UniProt Secondary Accession:Q9BQ16,O75705, Q6UW53, B2R7M7, B3KR67, B4DGK5, B4DHB4 B4DHV3, B4DI46, B4DJY3, E7EP61, F5H099,
UniProt Related Accession:Q9BQ16
Molecular Weight:49kDa
NCBI Full Name:Testican-3
NCBI Synonym Full Names:SPARC/osteonectin, cwcv and kazal like domains proteoglycan 3
NCBI Official Symbol:SPOCK3  
NCBI Official Synonym Symbols:TES-3; TICN3; HSAJ1454  
NCBI Protein Information:testican-3
UniProt Protein Name:Testican-3
UniProt Synonym Protein Names:SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 3
Protein Family:Testican
UniProt Gene Name:SPOCK3  
Anti-SPOCK3 Antibody (CAB12849)Western blot analysis of extracts of various cell lines, using SPOCK3 antibody (CAB12849) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.

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