Anti-Spermine synthase Antibody (CAB9154)
- SKU:
- CAB9154
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Frequently bought together:
Description
| Antibody Name: | Anti-Spermine synthase Antibody |
| Antibody SKU: | CAB9154 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-366 of human SMS (NP_004586.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HT-29, 293T, A375, Raji, Mouse brain, Mouse heart, Mouse kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-366 of human SMS (NP_004586.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAAA RHST LDFM LGAK ADGE TILK GLQS IFQE QGMA ESVH TWQD HGYL ATYT NKNG SFAN LRIY PHGL VLLD LQSY DGDA QGKE EIDS ILNK VEER MKEL SQDS TGRV KRLP PIVR GGAI DRYW PTAD GRLV EYDI DEVV YDED SPYQ NIKI LHSK QFGN ILIL SGDV NLAE SDLA YTRA IMGS GKED YTGK DVLI LGGG DGGI LCEI VKLK PKMV TMVE IDQM VIDG CKKY MRKT CGDV LDNL KGDC YQVL IEDC IPVL KRYA KEGR EFDY VIND LTAV PIST SPEE DSTW EFLR LILD LSMK VLKQ DGKY FTQG NCVN LTEA LSLY EEQL GRLY CPVE FSKE IVCV PSYL ELWV FYTV WKKA KP |
| Gene ID: | 6611 |
| Uniprot: | P52788 |
| Cellular Location: | |
| Calculated MW: | 35kDa/41kDa |
| Observed MW: | 41kDa |
| Synonyms: | SMS, MRSR, SPMSY, SRS, SpS |
| Background: | This gene encodes a protein belonging to the spermidine/spermin synthase family. Pseudogenes of this gene are located on chromosomes 1, 5, 6 and X. Mutations in this gene are associated with X-linked Snyder-Robinson mental retardation syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | SMS: an ubiquitous enzyme of polyamine metabolism. Synthesizes spermine from spermidine. |
| UniProt Protein Details: | Protein type:Amino Acid Metabolism - cysteine and methionine; Amino Acid Metabolism - arginine and proline; EC 2.5.1.22; Transferase; Other Amino Acids Metabolism - beta-alanine; Other Amino Acids Metabolism - glutathione Chromosomal Location of Human Ortholog: Xp22.1 Cellular Component: cytosol Molecular Function:spermidine synthase activity; spermine synthase activity Biological Process: methionine metabolic process; spermine biosynthetic process; polyamine metabolic process Disease: Mental Retardation, X-linked, Syndromic, Snyder-robinson Type |
| NCBI Summary: | This gene encodes a protein belonging to the spermidine/spermin synthase family. Pseudogenes of this gene are located on chromosomes 1, 5, 6 and X. Mutations in this gene are associated with X-linked Snyder-Robinson mental retardation syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012] |
| UniProt Code: | P52788 |
| NCBI GenInfo Identifier: | 21264341 |
| NCBI Gene ID: | 6611 |
| NCBI Accession: | NP_004586 |
| UniProt Secondary Accession: | P52788,O00544, Q9UQS1, A6NHA7, A6NI34, B2R9M0, |
| UniProt Related Accession: | P52788 |
| Molecular Weight: | 35,278 Da |
| NCBI Full Name: | spermine synthase isoform 1 |
| NCBI Synonym Full Names: | spermine synthase |
| NCBI Official Symbol: | SMS |
| NCBI Official Synonym Symbols: | SRS; SpS; MRSR; SPMSY |
| NCBI Protein Information: | spermine synthase |
| UniProt Protein Name: | Spermine synthase |
| UniProt Synonym Protein Names: | Spermidine aminopropyltransferase |
| UniProt Gene Name: | SMS |
| UniProt Entry Name: | SPSY_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SMS antibody (CAB9154) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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