Anti-Spermidine synthase Antibody (CAB8151)
- SKU:
- CAB8151
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Frequently bought together:
Description
| Antibody Name: | SRM Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB8151 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-302 of human SRM (NP_003123.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 22Rv1, HepG2, HeLa, Mouse liver, Mouse stomach, Mouse small intestine, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-302 of human SRM (NP_003123.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MEPG PDGP AASG PAAI REGW FRET CSLW PGQA LSLQ VEQL LHHR RSRY QDIL VFRS KTYG NVLV LDGV IQCT ERDE FSYQ EMIA NLPL CSHP NPRK VLII GGGD GGVL REVV KHPS VESV VQCE IDED VIQV SKKF LPGM AIGY SSSK LTLH VGDG FEFM KQNQ DAFD VIIT DSSD PMGP AESL FKES YYQL MKTA LKED GVLC CQGE CQWL HLDL IKEM RQFC QSLF PVVA YAYC TIPT YPSG QIGF MLCS KNPS TNFQ EPVQ PLTQ QQVA QMQL KYYN SDVH RAAF VLPE FARK ALND VS |
| Gene ID: | 6723 |
| Uniprot: | P19623 |
| Cellular Location: | |
| Calculated MW: | 33kDa |
| Observed MW: | 35kDa |
| Synonyms: | SRM, PAPT, SPDSY, SPS1, SRML1 |
| Background: | The polyamines putrescine, spermine, and spermidine are ubiquitous polycationic mediators of cell growth and differentiation. Spermidine synthase is one of four enzymes in the polyamine-biosynthetic pathway and carries out the final step of spermidine biosynthesis. This enzyme catalyzes the conversion of putrescine to spermidine using decarboxylated S-adenosylmethionine as the cofactor. |
| UniProt Protein Function: | SRM: Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM). Has a strong preference for putrescine as substrate, and has very low activity towards 1,3-diaminopropane. Has extremely low activity towards spermidine. Belongs to the spermidine/spermine synthase family. |
| UniProt Protein Details: | Protein type:Other Amino Acids Metabolism - glutathione; Amino Acid Metabolism - cysteine and methionine; Transferase; EC 2.5.1.16; Amino Acid Metabolism - arginine and proline; Other Amino Acids Metabolism - beta-alanine Chromosomal Location of Human Ortholog: 1p36-p22 Cellular Component: cytosol Molecular Function:protein binding; protein homodimerization activity; spermidine synthase activity Biological Process: polyamine metabolic process; spermidine biosynthetic process |
| NCBI Summary: | The polyamines putrescine, spermine, and spermidine are ubiquitous polycationic mediators of cell growth and differentiation. Spermidine synthase is one of four enzymes in the polyamine-biosynthetic pathway and carries out the final step of spermidine biosynthesis. This enzyme catalyzes the conversion of putrescine to spermidine using decarboxylated S-adenosylmethionine as the cofactor. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P19623 |
| NCBI GenInfo Identifier: | 134811 |
| NCBI Gene ID: | 6723 |
| NCBI Accession: | P19623.1 |
| UniProt Secondary Accession: | P19623,Q15511, B1AKP9, |
| UniProt Related Accession: | P19623 |
| Molecular Weight: | 33,825 Da |
| NCBI Full Name: | Spermidine synthase |
| NCBI Synonym Full Names: | spermidine synthase |
| NCBI Official Symbol: | SRM |
| NCBI Official Synonym Symbols: | PAPT; SPS1; SPDSY; SRML1 |
| NCBI Protein Information: | spermidine synthase |
| UniProt Protein Name: | Spermidine synthase |
| UniProt Synonym Protein Names: | Putrescine aminopropyltransferase |
| UniProt Gene Name: | SRM |
| UniProt Entry Name: | SPEE_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SRM antibody (CAB8151) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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