Anti-SPECC1L Antibody (CAB15798)
- SKU:
- CAB15798
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Frequently bought together:
Description
| Antibody Name: | Anti-SPECC1L Antibody |
| Antibody SKU: | CAB15798 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 200-500 of human SPECC1L (NP_056145.4). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human |
| Positive Samples: | LO2, HeLa, A375 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 200-500 of human SPECC1L (NP_056145.4). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LHLR NELR DMRA QLGI NEDH SEGD EKSE KETI MAHQ PTDV ESTL LQLQ EQNT AIRE ELNQ LKNE NRML KDRL NALG FSLE QRLD NSEK LFGY QSLS PEIT PGNQ SDGG GTLT SSVE GSAP GSVE DLLS QDEN TLMD HQHS NSMD NLDS ECSE VYQP LTSS DDAL DAPS SSES EGIP SIER SRKG SSGN ASEV SVAC LTER IHQM EENQ HSTS EELQ ATLQ ELAD LQQI TQEL NSEN ERLG EEKV ILME SLCQ QSDK LEHF SRQI EYFR SLLD EHHI SYVI DEDV KSGR YMEL EQRY MDLA E |
| Gene ID: | 23384 |
| Uniprot: | Q69YQ0 |
| Cellular Location: | Cell junction, Cytoplasm, cytoskeleton, gap junction, spindle |
| Calculated MW: | 120kDa/124kDa |
| Observed MW: | 168kDa |
| Synonyms: | SPECC1L, CYTSA, GBBB2, OBLFC1 |
| Background: | This gene encodes a coiled-coil domain containing protein. The encoded protein may play a critical role in actin-cytoskeletal reorganization during facial morphogenesis. Mutations in this gene are a cause of oblique facial clefting-1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A read-through transcript composed of SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and the downstream ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding. |
| UniProt Protein Function: | Function: Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration. Ref.10 |
| UniProt Protein Details: | Subunit structure: May interact with both microtubules and actin cytoskeleton. Subcellular location: Cytoplasm › cytoskeleton. Cytoplasm › cytoskeleton › spindle. Cell junction › gap junction. Note: Colocalizes with acetylated alpha-tubulin, gamma-tubulin and F-actin. Also observed in a ring around gamma-tubulin containing centrioles possibly in the microtubule organizing center. Ref.10 Involvement in Disease: Facial clefting, oblique, 1 (OBLFC1) [MIM:600251]: A rare form of facial clefting. A facial cleft is any of the fissures between the embryonic prominences that normally unite to form the face.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.10 Sequence similarities: Belongs to the cytospin-A family.Contains 1 CH (calponin-homology) domain. |
| NCBI Summary: | This gene encodes a coiled-coil domain containing protein. The encoded protein may play a critical role in actin-cytoskeletal reorganization during facial morphogenesis. Mutations in this gene are a cause of oblique facial clefting-1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A read-through transcript composed of SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and the downstream ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding. [provided by RefSeq, Jun 2013] |
| UniProt Code: | Q69YQ0 |
| NCBI GenInfo Identifier: | 224451082 |
| NCBI Gene ID: | 23384 |
| NCBI Accession: | NP_001138940.1 |
| UniProt Related Accession: | Q69YQ0 |
| Molecular Weight: | |
| NCBI Full Name: | cytospin-A |
| NCBI Synonym Full Names: | sperm antigen with calponin homology and coiled-coil domains 1 like |
| NCBI Official Symbol: | SPECC1L |
| NCBI Official Synonym Symbols: | TBHS; CYTSA; GBBB2; OBLFC1 |
| NCBI Protein Information: | cytospin-A |
| UniProt Protein Name: | Cytospin-A |
| UniProt Synonym Protein Names: | Renal carcinoma antigen NY-REN-22; Sperm antigen with calponin homology and coiled-coil domains 1-like |
| Protein Family: | Cytospin |
| UniProt Gene Name: | SPECC1L |
| UniProt Entry Name: | CYTSA_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SPECC1L antibody (CAB15798) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s. |
 | Immunohistochemistry of paraffin-embedded Human esophageal using SPECC1L Rabbit pAb (CAB15798) at dilution of 1:100 (40x lens). |
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