Anti-SP140 Antibody (CAB17634)
- SKU:
- CAB17634
- Product type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
| Antibody Name: | Anti-SP140 Antibody |
| Antibody SKU: | CAB17634 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human SP140 (NP_001265380). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse spleen, Mouse thymus, Rat thymus |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human SP140 (NP_001265380). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAQQ GQQG QMAS GDSN LNFR MVAE IQNV EGQN LQEQ VCPE PIFR FFRE NKVE IASA ITRP FPFL MGLR DRSF ISEQ MYEH FQEA FRNL VPVT RVMY CVLS ELEK TFGW SHLE ALFS RINL MAYP DLNE IYRS FQNV CYEH SPLQ MNNV NDLE DRPR LLPY GKQE NSNA CHEM DDIA VPQE |
| Gene ID: | 11262 |
| Uniprot: | Q13342 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | 98kDa |
 | Western blot - SP140 Polyclonal Antibody (CAB17634) |
| Synonyms: | LYSP100, LYSP100-A, LYSP100-B, SP140 |
| Background: | This gene encodes a member of the SP100 family of proteins, which are share common domains including an N-terminal homogeneously staining region domain followed by a SP100/autoimmune regulator/NucP41/P75/deformed epidermal autoregulatory factor domain, a plant homeobox zinc finger, and a bromodomain. The encoded protein is interferon-inducible and is expressed at high levels in the nuclei of leukocytes. Variants of this gene have been associated with multiple sclerosis, Crohn's disease, and chronic lymphocytic leukemia. Alternative splicing results in multiple variants. [provided by RefSeq, Aug 2016] |
| UniProt Protein Function: | SP140: Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body. May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 2q37.1 Cellular Component: nucleoplasm; PML body; cytoplasm; nuclear envelope; nucleus Molecular Function:protein binding; DNA binding; zinc ion binding; chromatin binding; transcription factor activity Biological Process: chromatin remodeling; regulation of transcription, DNA-dependent; defense response |
| UniProt Code: | Q13342 |
| NCBI GenInfo Identifier: | 217330601 |
| NCBI Gene ID: | 11262 |
| NCBI Accession: | NP_009168.4 |
| UniProt Secondary Accession: | Q13342,Q0VGE5, Q13341, Q3KR17, Q4ZG66, Q53TG1, Q6NSG4 Q92881, Q96TG3, E7ESH9, E7EUR5, E9PFJ6, |
| UniProt Related Accession: | Q13342 |
| Molecular Weight: | 91,673 Da |
| NCBI Full Name: | nuclear body protein SP140 isoform 1 |
| NCBI Synonym Full Names: | SP140 nuclear body protein |
| NCBI Official Symbol: | SP140 |
| NCBI Official Synonym Symbols: | LYSP100; LYSP100-A; LYSP100-B |
| NCBI Protein Information: | nuclear body protein SP140; speckled 140 kDa; nuclear autoantigen Sp-140; lymphoid-specific SP100 homolog; lymphoid-restricted homolog of Sp100 |
| UniProt Protein Name: | Nuclear body protein SP140 |
| UniProt Synonym Protein Names: | Lymphoid-restricted homolog of Sp100; Nuclear autoantigen Sp-140; Speckled 140 kDa |
| Protein Family: | Nuclear body protein |
| UniProt Gene Name: | SP140 |
| UniProt Entry Name: | SP140_HUMAN |
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