Anti-SOX6 Antibody (CAB7115)
- SKU:
- CAB7115
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Frequently bought together:
Description
| Antibody Name: | Anti-SOX6 Antibody |
| Antibody SKU: | CAB7115 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-74 of human SOX6 (NP_001139291.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-87MG, HT-29, Jurkat, Mouse kidney, Mouse skeletal muscle, Rat kidney, Rat skeletal muscle |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-74 of human SOX6 (NP_001139291.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MKGH GELQ GHER RMSS KQAT SPFA CAAD GEDA MTQD LTSR EKEE GSDQ HVAS HLPL HPIM HNKP HSEE LPTL VS |
| Gene ID: | 55553 |
| Uniprot: | P35712 |
| Cellular Location: | Nucleus |
| Calculated MW: | 88kDa/89kDa/91kDa |
| Observed MW: | 110kDa |
| Synonyms: | SOX6, HSSOX6, SOXD, SRY-box 6 |
| Background: | This gene encodes a member of the D subfamily of sex determining region y-related transcription factors that are characterized by a conserved DNA-binding domain termed the high mobility group box and by their ability to bind the minor groove of DNA. The encoded protein is a transcriptional activator that is required for normal development of the central nervous system, chondrogenesis and maintenance of cardiac and skeletal muscle cells. The encoded protein interacts with other family members to cooperatively activate gene expression. Alternative splicing results in multiple transcript variants. |
| NCBI Summary: | This gene encodes a member of the D subfamily of sex determining region y-related transcription factors that are characterized by a conserved DNA-binding domain termed the high mobility group box and by their ability to bind the minor groove of DNA. The encoded protein is a transcriptional activator that is required for normal development of the central nervous system, chondrogenesis and maintenance of cardiac and skeletal muscle cells. The encoded protein interacts with other family members to cooperatively activate gene expression. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009] |
| UniProt Code: | P35712 |
| NCBI GenInfo Identifier: | 1541310033 |
| NCBI Gene ID: | 55553 |
| NCBI Accession: | NP_059978 |
| UniProt Related Accession: | P35712 |
| Molecular Weight: | 89kDa |
| NCBI Full Name: | transcription factor SOX-6 isoform b |
| NCBI Synonym Full Names: | SRY-box 6 |
| NCBI Official Symbol: | SOX6 |
| NCBI Official Synonym Symbols: | SOXD; HSSOX6 |
| NCBI Protein Information: | transcription factor SOX-6 |
| UniProt Protein Name: | |
| Protein Family: | Transcription factor |
| UniProt Gene Name: |
 | Western blot analysis of extracts of various cell lines, using SOX6 antibody (CAB7115) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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