Anti-SOX30 Antibody (CAB11715)

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SKU:
CAB11715
Product type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling
Frequently bought together:

Description

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Antibody Name:Anti-SOX30 Antibody
Antibody SKU:CAB11715
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 604-753 of human SOX30 (NP_848511.1).
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:U-87MG, U-251MG, Mouse testis, Mouse brain, Rat testis
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 604-753 of human SOX30 (NP_848511.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:FGTP PRFS FHHP YFLP GPHY FPSS TCPY SRPP FGYG NFPS SMPE CLSY YEDR YPKH EGIF STLN RDYS FRDY SSEC THSE NSRS CENM NGTS YYNS HSHS GEEN LNPV PQLD IGTL ENVF TAPT STPS SIQQ VNVT DSDE EEEE KVLR DL
Gene ID:11063
Uniprot:O94993
Cellular Location:Nucleus
Calculated MW:54kDa/81kDa
Observed MW:90kDa
Synonyms:SOX30
Background:This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein acts as a transcriptional regulator when present in a complex with other proteins. It can activate p53 transcription to promote tumor cell apoptosis in lung cancer. The protein may be involved in the differentiation of developing male germ cells. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 5.
UniProt Protein Function:SOX30: Transcriptional activator. Binds to the DNA sequence 5'- ACAAT-3' and shows a preference for guanine residues surrounding this core motif. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:DNA-binding

Chromosomal Location of Human Ortholog: 5q33

Molecular Function:protein binding; sequence-specific DNA binding

Biological Process: response to corticosteroid stimulus

NCBI Summary:This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein acts as a transcriptional regulator when present in a complex with other proteins. It can activate p53 transcription to promote tumor cell apoptosis in lung cancer. The protein may be involved in the differentiation of developing male germ cells. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Apr 2015]
UniProt Code:O94993
NCBI GenInfo Identifier:20532269
NCBI Gene ID:11063
NCBI Accession:O94993.1
UniProt Secondary Accession:O94993,O94995, Q8IYX6,
UniProt Related Accession:O94993
Molecular Weight:54,290 Da
NCBI Full Name:Transcription factor SOX-30
NCBI Synonym Full Names:SRY-box 30
NCBI Official Symbol:SOX30  
NCBI Protein Information:transcription factor SOX-30
UniProt Protein Name:Transcription factor SOX-30
Protein Family:Transcription factor
UniProt Gene Name:SOX30  
UniProt Entry Name:SOX30_HUMAN
Anti-SOX30 Antibody (CAB11715)Western blot analysis of extracts of various cell lines, using SOX30 antibody (CAB11715) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.

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