Anti-SOX17 Antibody (CAB18858)

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SKU:
CAB18858
Product type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
VUR3
Frequently bought together:

Description

Product Name:SOX17 Rabbit pAb
Product Code:CAB18858
Size:50uL, 100uL
Synonyms:VUR3
Applications:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human SOX17.
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:293T, Mouse lung, Mouse testis, Mouse kidney, Rat kidney, Rat uterus
Immunogen:Recombinant protein of human SOX17.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:64321
Uniprot:Q9H6I2
Observed MW:50KDa
UniProt Protein Function:SOX17: Acts as transcription regulator that binds target promoter DNA and bends the DNA. Binds to the sequences 5'- AACAAT-'3 or 5'-AACAAAG-3'. Modulates transcriptional regulation via WNT3A. Inhibits Wnt signaling. Promotes degradation of activated CTNNB1. Plays a key role in the regulation of embryonic development. Required for normal looping of the embryonic heart tube. Required for normal development of the definitive gut endoderm. Probable transcriptional activator in the premeiotic germ cells. Defects in SOX17 are the cause of vesicoureteral reflux type 3 (VUR3). VUR3 is a disease belonging to the group of congenital anomalies of the kidney and urinary tract. It is characterized by the reflux of urine from the bladder into the ureters and sometimes into the kidneys, and is a risk factor for urinary tract infections. Primary disease results from a developmental defect of the ureterovesical junction. In combination with intrarenal reflux, the resulting inflammatory reaction may result in renal injury or scarring, also called reflux nephropathy. Extensive renal scarring impairs renal function and may predispose patients to hypertension, proteinuria, renal insufficiency and end-stage renal disease.
UniProt Protein Details:

Protein type:DNA-binding; Transcription regulation

Chromosomal Location of Human Ortholog: 8q11.23

Cellular Component: nucleoplasm; nucleus; transcription factor complex

Molecular Function:beta-catenin binding; protein binding; RNA polymerase II transcription factor activity, enhancer binding; transcription factor binding

Biological Process: angiogenesis; embryonic foregut morphogenesis; embryonic heart tube development; endoderm formation; heart looping; mRNA transcription from RNA polymerase II promoter; negative regulation of cell growth; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein destabilization; protein stabilization; regulation of embryonic development; regulation of transcription, DNA-dependent; vasculogenesis

Disease: Vesicoureteral Reflux 3

NCBI Summary:This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. [provided by RefSeq, Jul 2008]
UniProt Code:Q9H6I2
NCBI GenInfo Identifier:23822216
NCBI Gene ID:64321
NCBI Accession:Q9H6I2.1
UniProt Related Accession:Q9H6I2
Molecular Weight:44,117 Da
NCBI Full Name:Transcription factor SOX-17
NCBI Synonym Full Names:SRY-box 17
NCBI Official Symbol:SOX17  
NCBI Official Synonym Symbols:VUR3  
NCBI Protein Information:transcription factor SOX-17
UniProt Protein Name:Transcription factor SOX-17
Protein Family:Transcription factor
UniProt Gene Name:SOX17  

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