Anti-SORL1 Antibody (CAB13047)
- SKU:
- CAB13047
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-SORL1 Antibody |
| Antibody SKU: | CAB13047 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 2065-2214 of human SORL1 (NP_003096.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | SH-SY5Y, HepG2 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 2065-2214 of human SORL1 (NP_003096.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | DSAM NITA YLGN TTDN FFKI SNLK MGHN YTFT VQAR CLFG NQIC GEPA ILLY DELG SGAD ASAT QAAR STDV AAVV VPIL FLIL LSLG VGFA ILYT KHRR LQSS FTAF ANSH YSSR LGSA IFSS GDDL GEDD EDAP MITG FSDD VPMV IA |
| Gene ID: | 6653 |
| Uniprot: | Q92673 |
| Cellular Location: | Endosome, Golgi apparatus, Membrane, Secreted, Single-pass type I membrane protein |
| Calculated MW: | 248kDa |
| Observed MW: | 290kDa |
| Synonyms: | SORL1, C11orf32, LR11, LRP9, SORLA, SorLA-1, gp250 |
| Background: | This gene encodes a mosaic protein that belongs to at least two families: the vacuolar protein sorting 10 (VPS10) domain-containing receptor family, and the low density lipoprotein receptor (LDLR) family. The encoded protein also contains fibronectin type III repeats and an epidermal growth factor repeat. The encoded preproprotein is proteolytically processed to generate the mature receptor, which likely plays roles in endocytosis and sorting. Mutations in this gene may be associated with Alzheimer's disease. |
| UniProt Protein Function: | SORL1: Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor- associated protein (RAP). Could play a role in cell-cell interaction. Belongs to the VPS10-related sortilin family. SORL1 subfamily. |
| UniProt Protein Details: | Protein type:Cell surface; Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 11q24.1 Cellular Component: early endosome; endoplasmic reticulum; endosome; extracellular space; Golgi apparatus; Golgi cisterna; integral to plasma membrane; membrane; nuclear envelope lumen; recycling endosome; trans-Golgi network Molecular Function:ADP-ribosylation factor binding; beta-amyloid binding; low-density lipoprotein binding; protein binding; transmembrane receptor activity Biological Process: negative regulation of MAP kinase activity; negative regulation of neurogenesis; negative regulation of protein binding; negative regulation of protein oligomerization; positive regulation of protein catabolic process; post-Golgi vesicle-mediated transport; protein maturation; protein retention in Golgi; protein targeting; protein targeting to Golgi; protein targeting to lysosome; receptor-mediated endocytosis; regulation of smooth muscle cell migration Disease: Alzheimer Disease |
| NCBI Summary: | This gene encodes a mosaic protein that belongs to at least two families: the vacuolar protein sorting 10 (VPS10) domain-containing receptor family, and the low density lipoprotein receptor (LDLR) family. The encoded protein also contains fibronectin type III repeats and an epidermal growth factor repeat. The encoded preproprotein is proteolytically processed to generate the mature receptor, which likely plays roles in endocytosis and sorting. Mutations in this gene may be associated with Alzheimer's disease. [provided by RefSeq, Feb 2016] |
| UniProt Code: | Q92673 |
| NCBI GenInfo Identifier: | 649105467 |
| NCBI Gene ID: | 6653 |
| NCBI Accession: | AIC50396.1 |
| UniProt Secondary Accession: | Q92673,Q92856, B2RNX7, |
| UniProt Related Accession: | Q92673 |
| Molecular Weight: | 44.2 |
| NCBI Full Name: | WTAP, partial |
| NCBI Synonym Full Names: | sortilin related receptor 1 |
| NCBI Official Symbol: | SORL1 |
| NCBI Official Synonym Symbols: | LR11; LRP9; SORLA; gp250; SorLA-1; C11orf32 |
| NCBI Protein Information: | sortilin-related receptor |
| UniProt Protein Name: | Sortilin-related receptor |
| UniProt Synonym Protein Names: | Low-density lipoprotein receptor relative with 11 ligand-binding repeats; LDLR relative with 11 ligand-binding repeats; LR11; SorLA-1; Sorting protein-related receptor containing LDLR class A repeats; SorLA |
| Protein Family: | Pre-mRNA-splicing regulator |
| UniProt Gene Name: | SORL1 |
 | Western blot analysis of extracts of various cell lines, using SORL1 antibody (CAB13047) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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