Anti-SON Antibody (CAB16323)
- SKU:
- CAB16323
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Frequently bought together:
Description
| Antibody Name: | Anti-SON Antibody |
| Antibody SKU: | CAB16323 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 850-950 of human SON (NP_001278340.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | LO2, HeLa |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 850-950 of human SON (NP_001278340.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | TMDS QMLA TSSM DSQM LASG TMDS QMLA SGTM DAQM LASG TMDA QMLA SSTQ DSAM LGSK SPDP YRLA QDPY RLAQ DPYR LGHD PYRL GHDA YRLG QDPY R |
| Gene ID: | 6651 |
| Uniprot: | P18583 |
| Cellular Location: | |
| Calculated MW: | 264kDa |
| Observed MW: | 250kDa |
| Synonyms: | SON, BASS1, C21orf50, DBP-5, NREBP, SON3, TOKIMS |
| Background: | This gene encodes a protein that contains multiple simple repeats. The encoded protein binds RNA and promotes pre-mRNA splicing, particularly of transcripts with poor splice sites. The protein also recognizes a specific DNA sequence found in the human hepatitis B virus (HBV) and represses HBV core promoter activity. There is a pseudogene for this gene on chromosome 1. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | SON: RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that posses weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that posses weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'- GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. 10 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:RNA-binding; DNA-binding Chromosomal Location of Human Ortholog: 21q22.11 Cellular Component: nuclear speck; nucleoplasm Molecular Function:DNA binding; nucleic acid binding; protein binding; RNA binding; RS domain binding Biological Process: cytokinesis; microtubule cytoskeleton organization and biogenesis; mRNA processing; negative regulation of apoptosis; regulation of cell cycle; regulation of RNA splicing; RNA splicing |
| NCBI Summary: | This gene encodes a protein that contains multiple simple repeats. The encoded protein binds RNA and promotes pre-mRNA splicing, particularly of transcripts with poor splice sites. The protein also recognizes a specific DNA sequence found in the human hepatitis B virus (HBV) and represses HBV core promoter activity. There is a pseudogene for this gene on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] |
| UniProt Code: | P18583 |
| NCBI GenInfo Identifier: | 296453022 |
| NCBI Gene ID: | 6651 |
| NCBI Accession: | P18583.4 |
| UniProt Secondary Accession: | P18583,O14487, O95981, Q14120, Q6PKE0, Q9H7B1, D3DSF5 D3DSF6, E7ETE8, E7EU67, E7EVW3, E9PFQ2, |
| UniProt Related Accession: | P18583 |
| Molecular Weight: | 247,823 Da |
| NCBI Full Name: | Protein SON |
| NCBI Synonym Full Names: | SON DNA binding protein |
| NCBI Official Symbol: | SON |
| NCBI Official Synonym Symbols: | SON3; BASS1; DBP-5; NREBP; C21orf50 |
| NCBI Protein Information: | protein SON |
| UniProt Protein Name: | Protein SON |
| UniProt Synonym Protein Names: | Bax antagonist selected in saccharomyces 1; BASS1; Negative regulatory element-binding protein; NRE-binding protein; Protein DBP-5; SON3 |
| UniProt Gene Name: | SON |
| UniProt Entry Name: | SON_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SON antibody (CAB16323) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 8min. |
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