Anti-SNX5 Antibody (CAB13160)
- SKU:
- CAB13160
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-SNX5 Antibody |
| Antibody SKU: | CAB13160 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 145-404 of human SNX5 (NP_055241.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HepG2, U-87MG, Mouse thymus, Mouse brain, Mouse kidney, Rat thymus |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 145-404 of human SNX5 (NP_055241.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | VFLQ RLSS HPVL SKDR NFHV FLEY DQDL SVRR KNTK EMFG GFFK SVVK SADE VLFT GVKE VDDF FEQE KNFL INYY NRIK DSCV KADK MTRS HKNV ADDY IHTA ACLH SLAL EEPT VIKK YLLK VAEL FEKL RKVE GRVS SDED LKLT ELLR YYML NIEA AKDL LYRR TKAL IDYE NSNK ALDK ARLK SKDV KLAE AHQQ ECCQ KFEQ LSES AKEE LINF KRKR VAAF RKNL IEMS ELEI KHAR NNVS LLQS CIDL FKNN |
| Gene ID: | 27131 |
| Uniprot: | Q9Y5X3 |
| Cellular Location: | Cell membrane, Cell projection, Cytoplasm, Cytoplasmic side, Cytoplasmic vesicle membrane, Early endosome, Early endosome membrane, Endosome, Peripheral membrane protein, phagocytic cup, ruffle |
| Calculated MW: | 13kDa/46kDa |
| Observed MW: | 47kDa |
| Synonyms: | SNX5 |
| Background: | This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein functions in endosomal sorting, the phosphoinositide-signaling pathway, and macropinocytosis. This gene may play a role in the tumorigenesis of papillary thyroid carcinoma. Alternative splicing results in multiple transcript variants encoding different isoforms. |
| UniProt Protein Function: | SNX5: May be involved in several stages of intracellular trafficking. Plays a role in macropinocytosis. Plays a role in the internalization of EGFR after EGF stimulation. Belongs to the sorting nexin family. |
| UniProt Protein Details: | Protein type:Vesicle Chromosomal Location of Human Ortholog: 20p11 Cellular Component: ruffle; extrinsic to internal side of plasma membrane; cytoplasmic vesicle membrane; early endosome membrane; retromer complex; phagocytic cup Molecular Function:protein binding; phosphoinositide binding Biological Process: pinocytosis; intracellular protein transport; vesicle organization and biogenesis; retrograde transport, endosome to Golgi |
| NCBI Summary: | This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein functions in endosomal sorting, the phosphoinositide-signaling pathway, and macropinocytosis. This gene may play a role in the tumorigenesis of papillary thyroid carcinoma. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013] |
| UniProt Code: | Q9Y5X3 |
| NCBI GenInfo Identifier: | 10720289 |
| NCBI Gene ID: | 27131 |
| NCBI Accession: | Q9Y5X3.1 |
| UniProt Secondary Accession: | Q9Y5X3,Q52LC4, Q7KZN0, Q9BWP0, B7ZKN3, D3DW26, |
| UniProt Related Accession: | Q9Y5X3 |
| Molecular Weight: | 404 |
| NCBI Full Name: | Sorting nexin-5 |
| NCBI Synonym Full Names: | sorting nexin 5 |
| NCBI Official Symbol: | SNX5 |
| NCBI Protein Information: | sorting nexin-5 |
| UniProt Protein Name: | Sorting nexin-5 |
| Protein Family: | Sorting nexin |
| UniProt Gene Name: | SNX5 |
| UniProt Entry Name: | SNX5_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SNX5 antibody (CAB13160) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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