Anti-SNPH Antibody (CAB12300)
- SKU:
- CAB12300
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-SNPH Antibody |
| Antibody SKU: | CAB12300 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 300-425 of human SNPH (NP_055538.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:20 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse small intestine, Rat brain, Rat testis |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 300-425 of human SNPH (NP_055538.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MEAG VQAS CMQE RAIQ TDFV QYQP DLDT ILEK VTQA QVCG TDPE SGDR CPEL DAHP SGPR DPNS AVVV TVGD ELEA PEPI TRGP TPQR PGAN PNPG QSVS VVCP MEEE EEAA VAEK EPKS YWSR HY |
| Gene ID: | 9751 |
| Uniprot: | O15079 |
| Cellular Location: | Cell junction, Membrane, Single-pass membrane protein, synapse, synaptosome |
| Calculated MW: | 53kDa/57kDa |
| Observed MW: | 85kDa |
| Synonyms: | SNPH, bA314N13.5 |
| Background: | Syntaxin-1, synaptobrevin/VAMP, and SNAP25 interact to form the SNARE complex, which is required for synaptic vesicle docking and fusion. The protein encoded by this gene is membrane-associated and inhibits SNARE complex formation by binding free syntaxin-1. Expression of this gene appears to be brain-specific. Alternative splicing results in multiple transcript variants encoding different isoforms. |
| UniProt Protein Function: | syntaphilin: Inhibits SNARE complex formation by absorbing free syntaxin-1. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Vesicle Chromosomal Location of Human Ortholog: 20p13 Cellular Component: presynaptic membrane; neuron projection; cell soma; cytoplasmic microtubule; mitochondrial membrane; cytoplasm; integral to membrane; cell junction Molecular Function:syntaxin-1 binding Biological Process: neuron differentiation; neurotransmitter secretion; brain development; synaptic vesicle docking during exocytosis |
| NCBI Summary: | Syntaxin-1, synaptobrevin/VAMP, and SNAP25 interact to form the SNARE complex, which is required for synaptic vesicle docking and fusion. The protein encoded by this gene is membrane-associated and inhibits SNARE complex formation by binding free syntaxin-1. Expression of this gene appears to be brain-specific. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O15079 |
| NCBI GenInfo Identifier: | 21362912 |
| NCBI Gene ID: | 9751 |
| NCBI Accession: | O15079.1 |
| UniProt Secondary Accession: | O15079,Q8IYI3, |
| UniProt Related Accession: | O15079 |
| Molecular Weight: | 57,990 Da |
| NCBI Full Name: | Syntaphilin |
| NCBI Synonym Full Names: | syntaphilin |
| NCBI Official Symbol: | SNPH |
| NCBI Official Synonym Symbols: | bA314N13.5 |
| NCBI Protein Information: | syntaphilin |
| UniProt Protein Name: | Syntaphilin |
| Protein Family: | Syntaphilin |
| UniProt Gene Name: | SNPH |
| UniProt Entry Name: | SNPH_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SNPH antibody (CAB12300) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s. |
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