Anti-SMTN Antibody (CAB6745)
- SKU:
- CAB6745
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-SMTN Antibody |
| Antibody SKU: | CAB6745 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 65-325 of human SMTN (NP_001193946.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | MCF7, 5637, Mouse kidney, Rat lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 65-325 of human SMTN (NP_001193946.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | EGAL RKLL EVTA DLAE RRRI RSAI RELQ RQEL EREE EALA SKRF RAER QDNK ENWL HSQQ REAE QRAA LARL AGQL ESMN DVEE LTAL LRSA GEYE ERKL IRAA IRRV RAQE IEAA TLAG RLYS GRPN SGSR EDSK GLAA HRLE QCEV PERE EQEQ QAEV SKPT PTPE GTSQ DVTT VTLL LRAP PGST SSSP ASPS SSPT PASP EPPL EPAE AQCL TAEV PGSP EPPP SPPK TTSP EPQE SPTL PSTE GQVV NKLL SGPK E |
| Gene ID: | 6525 |
| Uniprot: | P53814 |
| Cellular Location: | Cytoplasm, cytoskeleton |
| Calculated MW: | 50kDa/98kDa/99kDa/101kDa |
| Observed MW: | 117kDa |
| Synonyms: | SMTN |
| Background: | This gene encodes a structural protein that is found exclusively in contractile smooth muscle cells. It associates with stress fibers and constitutes part of the cytoskeleton. This gene is localized to chromosome 22q12.3, distal to the TUPLE1 locus and outside the DiGeorge syndrome deletion. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. |
| UniProt Protein Function: | smoothelin: Structural protein of the cytoskeleton. Belongs to the smoothelin family. 4 isoforms of the human protein are produced by alternative promoter. |
| UniProt Protein Details: | Protein type:Cytoskeletal Chromosomal Location of Human Ortholog: 22q12.2 Cellular Component: nucleoplasm; cytoskeleton; cytoplasm; actin cytoskeleton Molecular Function:structural constituent of muscle; actin binding Biological Process: muscle development; smooth muscle contraction |
| NCBI Summary: | This gene encodes a structural protein that is found exclusively in contractile smooth muscle cells. It associates with stress fibers and constitutes part of the cytoskeleton. This gene is localized to chromosome 22q12.3, distal to the TUPLE1 locus and outside the DiGeorge syndrome deletion. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2011] |
| UniProt Code: | P53814 |
| NCBI GenInfo Identifier: | 338817991 |
| NCBI Gene ID: | 6525 |
| NCBI Accession: | P53814.7 |
| UniProt Secondary Accession: | P53814,O00569, O95769, O95937, Q8N4H8, Q8WWW1, Q8WWW2 Q9P1S8, Q9UIT1, Q9UIT2, |
| UniProt Related Accession: | P53814 |
| Molecular Weight: | 917 |
| NCBI Full Name: | Smoothelin |
| NCBI Synonym Full Names: | smoothelin |
| NCBI Official Symbol: | SMTN |
| NCBI Protein Information: | smoothelin |
| UniProt Protein Name: | Smoothelin |
| Protein Family: | Smoothelin |
| UniProt Gene Name: | SMTN |
| UniProt Entry Name: | SMTN_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SMTN antibody (CAB6745) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 5min. |
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