Anti-SMC2 Antibody (CAB17867)
- SKU:
- CAB17867
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Frequently bought together:
Description
| Antibody Name: | Anti-SMC2 Antibody |
| Antibody SKU: | CAB17867 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 700-900 of human SMC2 (NP_006435.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | MCF7, Raji, U-87MG, Mouse kidney, Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 700-900 of human SMC2 (NP_006435.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | EELA GLKN TAEK YRQL KQQW EMKT EEAD LLQT KLQQ SSYH KQQE ELDA LKKT IEES EETL KNTK EIQR KAEE KYEV LENK MKNA EAER EREL KDAQ KKLD CAKT KADA SSKK MKEK QQEV EAIT LELE ELKR EHTS YKQQ LEAV NEAI KSYE SQIE VMAA EVAK NKES VNKA QEEV TKQK EVIT AQDT VIKA KYAE VAKH K |
| Gene ID: | 10592 |
| Uniprot: | O95347 |
| Cellular Location: | Chromosome, Cytoplasm, Nucleus |
| Calculated MW: | 124kDa/135kDa |
| Observed MW: | 135kDa |
| Synonyms: | SMC2, CAP-E, CAPE, SMC-2, SMC2L1 |
| Background: |
| UniProt Protein Function: | SMC2L1: Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. Forms an heterodimer with SMC4. Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: BRRN1/CAPH, CNAP1/CAPD2 and CAPG. Belongs to the SMC family. SMC2 subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell cycle regulation Chromosomal Location of Human Ortholog: 9q31.1 Cellular Component: condensed chromosome; condensin complex; cytoplasm; cytosol; nuclear chromosome; nucleolus; nucleoplasm; nucleus Molecular Function:protein binding; protein heterodimerization activity Biological Process: mitotic chromosome condensation |
| UniProt Code: | O95347 |
| NCBI GenInfo Identifier: | 215273886 |
| NCBI Gene ID: | 10592 |
| NCBI Accession: | O95347.2 |
| UniProt Secondary Accession: | O95347,Q6IEE0, Q9P1P2, |
| UniProt Related Accession: | O95347 |
| Molecular Weight: | 124,926 Da |
| NCBI Full Name: | Structural maintenance of chromosomes protein 2 |
| NCBI Synonym Full Names: | structural maintenance of chromosomes 2 |
| NCBI Official Symbol: | SMC2 |
| NCBI Official Synonym Symbols: | CAPE; CAP-E; SMC-2; SMC2L1 |
| NCBI Protein Information: | structural maintenance of chromosomes protein 2 |
| UniProt Protein Name: | Structural maintenance of chromosomes protein 2 |
| UniProt Synonym Protein Names: | Chromosome-associated protein E; hCAP-E; XCAP-E homolog |
| UniProt Gene Name: | SMC2 |
| UniProt Entry Name: | SMC2_HUMAN |
 | Western blot analysis of extracts of various cells, using SMC2 antibody (CAB17867) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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