Anti-SMARCC1/BAF155 Antibody (CAB4275)
- SKU:
- CAB4275
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Neuroscience
Frequently bought together:
Description
| Antibody Name: | Anti-SMARCC1/BAF155 Antibody |
| Antibody SKU: | CAB4275 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human SMARCC1/BAF155 |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HeLa, HepG2, Mouse brain, Mouse testis |
| Immunogen: | A synthesized peptide derived from human SMARCC1/BAF155 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 6599 |
| Uniprot: | Q92922 |
| Cellular Location: | |
| Calculated MW: | 155kDa |
| Observed MW: | 155KDa |
| Synonyms: | BAF155, CRACC1, Rsc8, SRG3, SWI3 |
| Background: | The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and contains a predicted leucine zipper motif typical of many transcription factors. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | SMARCC1: a core component of the BAF (SWI/SNF) complex. This family of complexes remodels chromatin structures, enabling transcription factors to gain access to DNA. They play important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling is due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers. Belongs to the neural progenitors- specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain BAF53A and PHF10, are exchanged for homologous alternative BAF53B and BAF45B or BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand- bound VDR-mediated transrepression of the CYP27B1 gene. Component of 6 multiprotein chromatin-remodeling complexes: Swi/Snf-A (BAF), Swi/Snf-B (PBAF), Brm, Brg1(I), WINAC and Brg1(II). Each of the five complexes contains a catalytic subunit (either SMARCA4 or SMARCA2), and at least SMARCE1, BAF53A or BAF53B, SMARCC2 and SMARCB1. Other subunits specific to each of the complexes may also be present. Component of the BAF (hSWI/SNF) complex, which includes at least actin (ACTB), ARID1A, ARID1B, SMARCA2, SMARCA4, BAF53A, BAF53B, SMARCE1 SMARCC1, SMARCC2, SMARCB1, and one or more of SMARCD1, SMARCD2, or SMARCD3. In muscle cells, the BAF complex also contains DPF3. May also interact with the SIN3A histone deacetylase transcription repressor complex in conjunction with SMARCA2 and SMARCA4. The minimal complex composed of SMARCC1 and SMARCA4 seems to be able to associate with cyclin such as CCNE1 or transcription factors such as KLF1 or GATA1. Expressed in brain, heart, muscle, placenta, lung, liver, muscle, kidney and pancreas. Belongs to the SMARCC family. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 3p21.31 Cellular Component: nuclear chromatin; nucleoplasm; protein complex; SWI/SNF complex Molecular Function:nucleosomal DNA binding; protein binding; protein N-terminus binding Biological Process: ATP-dependent chromatin remodeling; chromatin remodeling; nucleosome disassembly; positive regulation of transcription, DNA-dependent |
| NCBI Summary: | The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and contains a predicted leucine zipper motif typical of many transcription factors. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q92922 |
| NCBI GenInfo Identifier: | 209572723 |
| NCBI Gene ID: | 6599 |
| NCBI Accession: | Q92922.3 |
| UniProt Secondary Accession: | Q92922,Q17RS0, Q6P172, Q8IWH2, |
| UniProt Related Accession: | Q92922 |
| Molecular Weight: | 122,867 Da |
| NCBI Full Name: | SWI/SNF complex subunit SMARCC1 |
| NCBI Synonym Full Names: | SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1 |
| NCBI Official Symbol: | SMARCC1 |
| NCBI Official Synonym Symbols: | Rsc8; SRG3; SWI3; BAF155; CRACC1 |
| NCBI Protein Information: | SWI/SNF complex subunit SMARCC1 |
| UniProt Protein Name: | SWI/SNF complex subunit SMARCC1 |
| UniProt Synonym Protein Names: | BRG1-associated factor 155; BAF155; SWI/SNF complex 155 kDa subunit; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1 |
| Protein Family: | SWI/SNF complex |
| UniProt Gene Name: | SMARCC1 |
| UniProt Entry Name: | SMRC1_HUMAN |
 | Western blot - SMARCC1/BAF155 Rabbit mAb (CAB4275) |
Related Products
![Anti-SMARCC1 Antibody (CAB6128)[KO Validated]](https://cdn11.bigcommerce.com/s-39x6lpnvxv/images/stencil/590x590/products/26687/24876/anti-smarcc1-antibody-cab6128ko-validated__90251__85345.1644314063.jpg?c=1 "Anti-SMARCC1 Antibody (CAB6128)[KO Validated]")
Anti-SMARCC1 Antibody (CAB6128)[KO Validated]
Human anti-EPO antibody(anti-Erythropoietin antibody) ELISA Kit
