Anti-SLIT1 Antibody (CAB16430)
- SKU:
- CAB16430
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Frequently bought together:
Description
| Antibody Name: | Anti-SLIT1 Antibody |
| Antibody SKU: | CAB16430 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1315-1534 of human SLIT1 (NP_003052.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | 293T |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1315-1534 of human SLIT1 (NP_003052.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | RNLY INNE LQDF TKTQ MKPG VVPG CEPC RKLY CLHG ICQP NATP GPMC HCEA GWVG LHCD QPAD GPCH GHKC VHGQ CVPL DALS YSCQ CQDG YSGA LCNQ AGAL AEPC RGLQ CLHG HCQA SGTK GAHC VCDP GFSG ELCE QESE CRGD PVRD FHQV QRGY AICQ TTRP LSWV ECRG SCPG QGCC QGLR LKRR KFTF ECSD GTSF AEEV EKPT KCGC ALCA |
| Gene ID: | 6585 |
| Uniprot: | O75093 |
| Cellular Location: | Secreted |
| Calculated MW: | 90kDa/167kDa |
| Observed MW: | 168kDa |
| Synonyms: | SLIT1, MEGF4, SLIL1, SLIT-1, SLIT3 |
| Background: |
| UniProt Protein Function: | SLIT1: Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 10q23.3-q24 Cellular Component: extracellular space; proteinaceous extracellular matrix Molecular Function:heparin binding; Roundabout binding Biological Process: axon extension involved in axon guidance; axon guidance; chemorepulsion involved in embryonic olfactory bulb interneuron migration; motor axon guidance; negative chemotaxis; negative regulation of synaptogenesis; regulation of axonogenesis |
| UniProt Code: | O75093 |
| NCBI GenInfo Identifier: | 145559530 |
| NCBI Gene ID: | 6585 |
| NCBI Accession: | O75093.4 |
| UniProt Secondary Accession: | O75093,Q5T0V1, Q8WWZ2, Q9UIL7, |
| UniProt Related Accession: | O75093 |
| Molecular Weight: | 90,633 Da |
| NCBI Full Name: | Slit homolog 1 protein |
| NCBI Synonym Full Names: | slit guidance ligand 1 |
| NCBI Official Symbol: | SLIT1 |
| NCBI Official Synonym Symbols: | MEGF4; SLIL1; SLIT3; SLIT-1 |
| NCBI Protein Information: | slit homolog 1 protein |
| UniProt Protein Name: | Slit homolog 1 protein |
| UniProt Synonym Protein Names: | Multiple epidermal growth factor-like domains protein 4; Multiple EGF-like domains protein 4 |
| Protein Family: | Slit homolog 1 protein |
| UniProt Gene Name: | SLIT1 |
| UniProt Entry Name: | SLIT1_HUMAN |
 | Western blot analysis of extracts of 293T cells, using SLIT1 antibody (CAB16430) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 3min. |
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