Anti-SLC9A3R1 Antibody (CAB0146)
- SKU:
- CAB0146
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
| Antibody Name: | Anti-SLC9A3R1 Antibody |
| Antibody SKU: | CAB0146 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 189-358 of human SLC9A3R1 (NP_004243.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:1000 - 1:4000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HepG2, 293T, HT-29, MCF7, Mouse liver, Mouse kidney, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 189-358 of human SLC9A3R1 (NP_004243.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | EASG LRAQ DRIV EVNG VCME GKQH GDVV SAIR AGGD ETKL LVVD RETD EFFK KCRV IPSQ EHLN GPLP VPFT NGEI QKEN SREA LAEA ALES PRPA LVRS ASSD TSEE LNSQ DSPP KQDS TAPS STSS SDPI LDFN ISLA MAKE RAHQ KRSS KRAP QMDW SKKN ELFS NL |
| Gene ID: | 9368 |
| Uniprot: | O14745 |
| Cellular Location: | Apical cell membrane, Cell projection, Cytoplasm, Endomembrane system, Peripheral membrane protein, filopodium, microvillus, ruffle |
| Calculated MW: | 22kDa/38kDa |
| Observed MW: | 50kDa |
| Synonyms: | SLC9A3R1, EBP50, NHERF, NHERF-1, NHERF1, NPHLOP2 |
| Background: | This gene encodes a sodium/hydrogen exchanger regulatory cofactor. The protein interacts with and regulates various proteins including the cystic fibrosis transmembrane conductance regulator and G-protein coupled receptors such as the beta2-adrenergic receptor and the parathyroid hormone 1 receptor. The protein also interacts with proteins that function as linkers between integral membrane and cytoskeletal proteins. The protein localizes to actin-rich structures including membrane ruffles, microvilli, and filopodia. Mutations in this gene result in hypophosphatemic nephrolithiasis/osteoporosis type 2, and loss of heterozygosity of this gene is implicated in breast cancer. |
| NCBI Summary: | This gene encodes a sodium/hydrogen exchanger regulatory cofactor. The protein interacts with and regulates various proteins including the cystic fibrosis transmembrane conductance regulator and G-protein coupled receptors such as the beta2-adrenergic receptor and the parathyroid hormone 1 receptor. The protein also interacts with proteins that function as linkers between integral membrane and cytoskeletal proteins. The protein localizes to actin-rich structures including membrane ruffles, microvilli, and filopodia. Mutations in this gene result in hypophosphatemic nephrolithiasis/osteoporosis type 2, and loss of heterozygosity of this gene is implicated in breast cancer.[provided by RefSeq, Sep 2009] |
| UniProt Code: | O14745 |
| NCBI GenInfo Identifier: | 4759140 |
| NCBI Gene ID: | 9368 |
| NCBI Accession: | NP_004243.1 |
| UniProt Secondary Accession: | O14745,Q9JJ19, |
| UniProt Related Accession: | O14745 |
| Molecular Weight: | 50kDa |
| NCBI Full Name: | Na(+)/H(+) exchange regulatory cofactor NHE-RF1 |
| NCBI Synonym Full Names: | SLC9A3 regulator 1 |
| NCBI Official Symbol: | SLC9A3R1 |
| NCBI Official Synonym Symbols: | EBP50; NHERF; NHERF1; NHERF-1; NPHLOP2 |
| NCBI Protein Information: | Na(+)/H(+) exchange regulatory cofactor NHE-RF1 |
| UniProt Protein Name: | Na(+)/H(+) exchange regulatory cofactor NHE-RF1 |
| UniProt Synonym Protein Names: | Ezrin-radixin-moesin-binding phosphoprotein 50; EBP50; Regulatory cofactor of Na(+)/H(+) exchanger; Sodium-hydrogen exchanger regulatory factor 1; Solute carrier family 9 isoform A3 regulatory factor 1 |
| UniProt Gene Name: | SLC9A3R1 |
| UniProt Entry Name: | NHRF1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SLC9A3R1 antibody (CAB0146) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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