Anti-SLC7A9 Antibody (CAB12848)
- SKU:
- CAB12848
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| Antibody Name: | Anti-SLC7A9 Antibody |
| Antibody SKU: | CAB12848 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human SLC7A9 (NP_055085.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:1000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | LO2, Mouse kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human SLC7A9 (NP_055085.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MGDT GLRK RRED EKSI QSQE PKTT SLQK ELGL ISGI SIIV GTII GSGI FVSP KSVL SNTE AVGP CLII WAAC GVLA TLGA LCFA ELGT MITK SGGE YPYL |
| Gene ID: | 11136 |
| Uniprot: | P82251 |
| Cellular Location: | Apical cell membrane, Multi-pass membrane protein |
| Calculated MW: | 53kDa |
| Observed MW: | 53kDa |
| Synonyms: | SLC7A9, BAT1, CSNU3 |
| Background: | This gene encodes a protein that belongs to a family of light subunits of amino acid transporters. This protein plays a role in the high-affinity and sodium-independent transport of cystine and neutral and dibasic amino acids, and appears to function in the reabsorption of cystine in the kidney tubule. Mutations in this gene cause non-type I cystinuria, a disease that leads to cystine stones in the urinary system due to impaired transport of cystine and dibasic amino acids. Alternate transcript variants, which encode the same protein, have been found for this gene. |
| UniProt Protein Function: | SLC7A9: Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system b(0,+)-like activity). Thought to be responsible for the high- affinity reabsorption of cystine in the kidney tubule. Defects in SLC7A9 are a cause of non-type I cystinuria (CSNU). CSNU arises from impaired transport of cystine and dibasic amino acids through the epithelial cells of the renal tubule and gastrointestinal tract. Three types of cystinuria have been described: type I (fully recessive or silent); type II (high excretor); type III (moderate excretor). Defects in SLC7A9 are associated with type II and type III cystinuria. They also might account for some non-classic type I cystinuria cases. Belongs to the amino acid-polyamine-organocation (APC) superfamily. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Chromosomal Location of Human Ortholog: 19q13.11 Cellular Component: apical plasma membrane; brush border membrane; integral to plasma membrane; plasma membrane Molecular Function:antiporter activity; L-cystine transmembrane transporter activity; neutral amino acid transmembrane transporter activity; peptide antigen binding; protein binding Biological Process: amino acid transport; L-cystine transport; leukocyte migration; neutral amino acid transport; protein complex assembly Disease: Cystinuria |
| NCBI Summary: | This gene encodes a protein that belongs to a family of light subunits of amino acid transporters. This protein plays a role in the high-affinity and sodium-independent transport of cystine and neutral and dibasic amino acids, and appears to function in the reabsorption of cystine in the kidney tubule. Mutations in this gene cause non-type I cystinuria, a disease that leads to cystine stones in the urinary system due to impaired transport of cystine and dibasic amino acids. Alternate transcript variants, which encode the same protein, have been found for this gene. [provided by RefSeq, Jul 2011] |
| UniProt Code: | P82251 |
| NCBI GenInfo Identifier: | 12585187 |
| NCBI Gene ID: | 11136 |
| NCBI Accession: | P82251.1 |
| UniProt Secondary Accession: | P82251,B2R9A6, |
| UniProt Related Accession: | P82251 |
| Molecular Weight: | Calculated: 53kDaObserved:53kDa |
| NCBI Full Name: | b(0,+)-type amino acid transporter 1 |
| NCBI Synonym Full Names: | solute carrier family 7 member 9 |
| NCBI Official Symbol: | SLC7A9 |
| NCBI Official Synonym Symbols: | BAT1; CSNU3 |
| NCBI Protein Information: | B(0,+)-type amino acid transporter 1 |
| UniProt Protein Name: | b(0,+)-type amino acid transporter 1 |
| UniProt Synonym Protein Names: | Glycoprotein-associated amino acid transporter b0,+AT1; Solute carrier family 7 member 9 |
| Protein Family: | b(0,+)-type amino acid transporter |
| UniProt Gene Name: | SLC7A9 |
 | Western blot analysis of extracts of various cell lines, using SLC7A9 antibody (CAB12848) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
 | Immunofluorescence analysis of rat kidney using SLC7A9 antibody (CAB12848) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of human kidney cancer using SLC7A9 antibody (CAB12848) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of human kidney cancer using SLC7A9 antibody (CAB12848) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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