Anti-SLC4A7 항체 (CAB10271)

Antibody Name:	Anti-SLC4A7 Antibody
Antibody SKU:	CAB10271
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human, Mouse
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 240-400 of human SLC4A7 (NP_003606.3).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human, Mouse
Positive Samples:	Mouse liver

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 240-400 of human SLC4A7 (NP_003606.3).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	KHSD PHLL ERNG EGLS ASRH SLRT GLSA SNLS LRGE SPLS LLLG HLLP SSRA GTPA GSRC TTPV PTPQ NSPP SSPS ISRL TSRS SQES QRQA PELL VSPA SDDI PTVV IHPP EEDL EAAL KGEE QKNE ENVD LTPG ILAS PQSA PGNL DNSK SGEI KGNG S
Gene ID:	9497
Uniprot:	Q9Y6M7
Cellular Location:	Apical cell membrane, Basolateral cell membrane, Cell projection, Multi-pass membrane protein, stereocilium
Calculated MW:	52kDa/63kDa/89kDa/112-140kDa
Observed MW:	160kDa

Synonyms:

SLC4A7, NBC2, NBC3, NBCN1, SBC2, SLC4A6

Background:

This locus encodes a sodium bicarbonate cotransporter. The encoded transmembrane protein appears to transport sodium and bicarbonate ions in a 1:1 ratio, and is thus considered an electroneutral cotransporter. The encoded protein likely plays a critical role in regulation of intracellular pH involved in visual and auditory sensory transmission. Alternatively spliced transcript variants encoding distinct isoforms have been described.

UniProt Protein Function:	SLC4A7: Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry. Regulates intracellular pH and may play a role in bicarbonate salvage in secretory epithelia. May also have an associated sodium channel activity. Belongs to the anion exchanger (TC 2.A.31) family. 5 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Chromosomal Location of Human Ortholog: 3p24.1 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:anion transmembrane transporter activity; sodium:bicarbonate symporter activity Biological Process: auditory receptor cell development; bicarbonate transport; regulation of intracellular pH
NCBI Summary:	This locus encodes a sodium bicarbonate cotransporter. The encoded transmembrane protein appears to transport sodium and bicarbonate ions in a 1:1 ratio, and is thus considered an electroneutral cotransporter. The encoded protein likely plays a critical role in regulation of intracellular pH involved in visual and auditory sensory transmission. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Apr 2012]
UniProt Code:	Q9Y6M7
NCBI GenInfo Identifier:	229462789
NCBI Gene ID:	9497
NCBI Accession:	Q9Y6M7.2
UniProt Secondary Accession:	Q9Y6M7,A6NIA8, B2CI53, B5M449, B5M451, B5M452, B5M453 B6DY52, B6DY53, C9JST9, D3K174, D3K175,
UniProt Related Accession:	Q9Y6M7
Molecular Weight:	136kDa
NCBI Full Name:	Sodium bicarbonate cotransporter 3
NCBI Synonym Full Names:	solute carrier family 4 member 7
NCBI Official Symbol:	SLC4A7
NCBI Official Synonym Symbols:	NBC2; NBC3; SBC2; NBCN1; SLC4A6
NCBI Protein Information:	sodium bicarbonate cotransporter 3
UniProt Protein Name:	Sodium bicarbonate cotransporter 3
UniProt Synonym Protein Names:	Electroneutral Na/HCO(3) cotransporter; Sodium bicarbonate cotransporter 2; Sodium bicarbonate cotransporter 2b; Bicarbonate transporter; Solute carrier family 4 member 7
Protein Family:	Sodium bicarbonate cotransporter
UniProt Gene Name:	SLC4A7

Western blot analysis of extracts of mouse liver, using SLC4A7 antibody (CAB10271) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 90s.

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)