Anti-SLC4A10 Antibody (CAB13810)
- SKU:
- CAB13810
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| Antibody Name: | Anti-SLC4A10 Antibody |
| Antibody SKU: | CAB13810 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 640-725 of human SLC4A10 (NP_001171486.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | 293T, Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 640-725 of human SLC4A10 (NP_001171486.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ALEK LFEL SEAY PINM HNDL ELLT QYSC NCVE PHNP SNGT LKEW RESN ISAS DIIW ENLT VSEC KSLH GEYV GRAC GHDH PYVP DV |
| Gene ID: | 57282 |
| Uniprot: | Q6U841 |
| Cellular Location: | Cell membrane, Multi-pass membrane protein |
| Calculated MW: | 46kDa/122kDa/123kDa/125kDa |
| Observed MW: | 180kDa |
| Synonyms: | SLC4A10, NBCn2, NCBE |
| Background: | This gene belongs to a small family of sodium-coupled bicarbonate transporters (NCBTs) that regulate the intracellular pH of neurons, the secretion of bicarbonate ions across the choroid plexus, and the pH of the brain extracellular fluid. The protein encoded by this gene was initially identified as a sodium-driven chloride bicarbonate exchanger (NCBE) though there is now evidence that its sodium/bicarbonate cotransport activity is independent of any chloride ion countertransport under physiological conditions. This gene is now classified as a member A10 of the SLC4 family of transmembrane solute carriers. Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
| UniProt Protein Function: | Electrogenic sodium/bicarbonate cotransporter in exchange for intracellular chloride. Plays an important role in regulating intracellular pH. |
| NCBI Summary: | This gene belongs to a small family of sodium-coupled bicarbonate transporters (NCBTs) that regulate the intracellular pH of neurons, the secretion of bicarbonate ions across the choroid plexus, and the pH of the brain extracellular fluid. The protein encoded by this gene was initially identified as a sodium-driven chloride bicarbonate exchanger (NCBE) though there is now evidence that its sodium/bicarbonate cotransport activity is independent of any chloride ion countertransport under physiological conditions. This gene is now classified as a member A10 of the SLC4 family of transmembrane solute carriers. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010] |
| UniProt Code: | Q6U841 |
| NCBI GenInfo Identifier: | 295821221 |
| NCBI Gene ID: | 57282 |
| NCBI Accession: | NP_001171486.1 |
| UniProt Secondary Accession: | Q6U841,Q4ZFX6, Q8TCP2, Q9HCQ6, B7Z1R0, B7Z2J0, B7ZLC5 B9EG69, F8W675, |
| UniProt Related Accession: | Q6U841 |
| Molecular Weight: | Calculated: 46kDa; 122kDa; 123kDa; 125kDaObserved: 180kDa |
| NCBI Full Name: | sodium-driven chloride bicarbonate exchanger isoform 1 |
| NCBI Synonym Full Names: | solute carrier family 4 member 10 |
| NCBI Official Symbol: | SLC4A10 |
| NCBI Official Synonym Symbols: | NCBE; NBCn2 |
| NCBI Protein Information: | sodium-driven chloride bicarbonate exchanger |
| UniProt Protein Name: | Sodium-driven chloride bicarbonate exchanger |
| UniProt Synonym Protein Names: | Solute carrier family 4 member 10 |
| Protein Family: | Sodium-driven chloride bicarbonate exchanger |
| UniProt Gene Name: | SLC4A10 |
 | Western blot analysis of extracts of various cell lines, using SLC4A10 antibody (CAB13810) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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