Anti-SLC34A1 항체 (CAB6742)

Antibody Name:	Anti-SLC34A1 Antibody
Antibody SKU:	CAB6742
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IF
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-103 of human SLC34A1 (NP_003043.3).

Application:	WB IF
Recommended Dilution:	WB 1:500 - 1:2000 IF 1:10 - 1:100
Reactivity:	Human, Mouse, Rat
Positive Samples:	HT-29, SW620, Mouse kidney

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-103 of human SLC34A1 (NP_003043.3).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	MLSY GERL GSPA VSPL PVRG GHVM RGTA FAYV PSPQ VLHR IPGT SAYA FPSL GPVA LAEH TCPC GEVL ERHE PLPA KLAL EEEQ KPES RLVP KLRQ AGAM LLK
Gene ID:	6569
Uniprot:	Q06495
Cellular Location:	Membrane, Multi-pass membrane protein
Calculated MW:	36kDa/68kDa
Observed MW:	69kDa

Synonyms:	SLC34A1, FRTS2, HCINF2, NAPI-3, NPHLOP1, NPT2, NPTIIa, SLC11, SLC17A2
Background:	This gene encodes a member of the type II sodium-phosphate cotransporter family. Mutations in this gene are associated with hypophosphatemia nephrolithiasis/osteoporosis 1. Alternative splicing results in multiple transcript variants.

UniProt Protein Function:	SLC34A1: May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 70-80% of the apical influx. Defects in SLC34A1 are the cause of hypophosphatemic nephrolithiasis/osteoporosis type 1 (NPHLOP1). Hypophosphatemia results from idiopathic renal phosphate loss. It contributes to the pathogenesis of hypophosphatemic urolithiasis (formation of urinary calculi) as well to that of hypophosphatemic osteoporosis (bone demineralization). Defects in SLC34A1 are the cause of Fanconi renotubular syndrome type 2 (FRTS2). It is a disease resulting from a generalized dysfunction of the proximal kidney tubule leading to decreased solute and water reabsorption. Patients have polydipsia and polyuria with phosphaturia, glycosuria and aminoaciduria. They may develop hypophosphatemic rickets or osteomalacia, acidosis and a tendency toward dehydration. Some eventually develop renal insufficiency. Belongs to the SLC34A transporter family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Transporter, SLC family; Transporter; Membrane protein, multi-pass; Membrane protein, integral Chromosomal Location of Human Ortholog: 5q35 Cellular Component: cell surface; integral to plasma membrane; perinuclear region of cytoplasm; basolateral plasma membrane; brush border membrane; apical plasma membrane; plasma membrane; endosome; lipid raft Molecular Function:protein binding; protein homodimerization activity; symporter activity; protein complex binding; sodium-dependent phosphate transmembrane transporter activity; PDZ domain binding Biological Process: response to drug; indole metabolic process; ossification; glycoprotein metabolic process; sodium ion transport; bone remodeling; response to estradiol stimulus; response to vitamin A; response to mercury ion; response to magnesium ion; response to cadmium ion; phosphate transport; response to lead ion; ion transport; phosphate ion homeostasis; positive regulation of membrane potential; kidney development; transmembrane transport; protein homooligomerization Disease: Fanconi Renotubular Syndrome 2; Nephrolithiasis/osteoporosis, Hypophosphatemic, 1
NCBI Summary:	This gene encodes a member of the type II sodium-phosphate cotransporter family. Mutations in this gene are associated with hypophosphatemia nephrolithiasis/osteoporosis 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]
UniProt Code:	Q06495
NCBI GenInfo Identifier:	730113
NCBI Gene ID:	6569
NCBI Accession:	Q06495.1
UniProt Secondary Accession:	Q06495,B4DPE3,
UniProt Related Accession:	Q06495
Molecular Weight:	639
NCBI Full Name:	Sodium-dependent phosphate transport protein 2A
NCBI Synonym Full Names:	solute carrier family 34 (type II sodium/phosphate cotransporter), member 1
NCBI Official Symbol:	SLC34A1
NCBI Official Synonym Symbols:	NPT2; FRTS2; SLC11; NAPI-3; NPTIIa; NPHLOP1; SLC17A2
NCBI Protein Information:	sodium-dependent phosphate transport protein 2A; naPi-2a; Na(+)/Pi cotransporter 2A; sodium/phosphate co-transporter; sodium/phosphate cotransporter 2A; solute carrier family 34 member 1; Na+-phosphate cotransporter type II; sodium-phosphate transport protein 2A; Na(+)-dependent phosphate cotransporter 2A; renal sodium-dependent phosphate transporter; solute carrier family 17 (sodium phosphate), member 2; solute carrier family 34 (sodium phosphate), member 1
UniProt Protein Name:	Sodium-dependent phosphate transport protein 2A
UniProt Synonym Protein Names:	Na(+)-dependent phosphate cotransporter 2A; NaPi-3; Sodium/phosphate cotransporter 2A; Na(+)/Pi cotransporter 2A; NaPi-2a; Solute carrier family 34 member 1
Protein Family:	Sodium-dependent phosphate transport protein
UniProt Gene Name:	SLC34A1
UniProt Entry Name:	NPT2A_HUMAN

	Western blot analysis of extracts of various cell lines, using SLC34A1 antibody (CAB6742) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
	Immunofluorescence analysis of HeLa cells using SLC34A1 antibody (CAB6742). Blue: DAPI for nuclear staining.

Antibodies

Anti-SLC34A1 Antibody (CAB13634)

Anti-SLC34A1 Antibody (CAB13635)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)