Anti-SLC34A1 Antibody (CAB13635)
- SKU:
- CAB13635
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| Antibody Name: | Anti-SLC34A1 Antibody |
| Antibody SKU: | CAB13635 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human SLC34A1 |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 293T, A-549, U-87MG, Mouse kidney, Rat lung |
| Immunogen: | Recombinant protein of human SLC34A1 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 6569 |
| Uniprot: | Q06495 |
| Cellular Location: | Membrane, Multi-pass membrane protein |
| Calculated MW: | 36kDa/68kDa |
| Observed MW: | 72kDa |
| Synonyms: | SLC34A1, FRTS2, HCINF2, NAPI-3, NPHLOP1, NPT2, NPTIIa, SLC11, SLC17A2 |
| Background: | This gene encodes a member of the type II sodium-phosphate cotransporter family. Mutations in this gene are associated with hypophosphatemia nephrolithiasis/osteoporosis 1. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | SLC34A1: May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 70-80% of the apical influx. Defects in SLC34A1 are the cause of hypophosphatemic nephrolithiasis/osteoporosis type 1 (NPHLOP1). Hypophosphatemia results from idiopathic renal phosphate loss. It contributes to the pathogenesis of hypophosphatemic urolithiasis (formation of urinary calculi) as well to that of hypophosphatemic osteoporosis (bone demineralization). Defects in SLC34A1 are the cause of Fanconi renotubular syndrome type 2 (FRTS2). It is a disease resulting from a generalized dysfunction of the proximal kidney tubule leading to decreased solute and water reabsorption. Patients have polydipsia and polyuria with phosphaturia, glycosuria and aminoaciduria. They may develop hypophosphatemic rickets or osteomalacia, acidosis and a tendency toward dehydration. Some eventually develop renal insufficiency. Belongs to the SLC34A transporter family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transporter, SLC family; Transporter; Membrane protein, multi-pass; Membrane protein, integral Chromosomal Location of Human Ortholog: 5q35 Cellular Component: cell surface; integral to plasma membrane; perinuclear region of cytoplasm; basolateral plasma membrane; brush border membrane; apical plasma membrane; plasma membrane; endosome; lipid raft Molecular Function:protein binding; protein homodimerization activity; symporter activity; protein complex binding; sodium-dependent phosphate transmembrane transporter activity; PDZ domain binding Biological Process: response to drug; indole metabolic process; ossification; glycoprotein metabolic process; sodium ion transport; bone remodeling; response to estradiol stimulus; response to vitamin A; response to mercury ion; response to magnesium ion; response to cadmium ion; phosphate transport; response to lead ion; ion transport; phosphate ion homeostasis; positive regulation of membrane potential; kidney development; transmembrane transport; protein homooligomerization Disease: Fanconi Renotubular Syndrome 2; Nephrolithiasis/osteoporosis, Hypophosphatemic, 1 |
| NCBI Summary: | This gene encodes a member of the type II sodium-phosphate cotransporter family. Mutations in this gene are associated with hypophosphatemia nephrolithiasis/osteoporosis 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009] |
| UniProt Code: | Q06495 |
| NCBI GenInfo Identifier: | 730113 |
| NCBI Gene ID: | 6569 |
| NCBI Accession: | Q06495.1 |
| UniProt Secondary Accession: | Q06495,B4DPE3, |
| UniProt Related Accession: | Q06495 |
| Molecular Weight: | 639 |
| NCBI Full Name: | Sodium-dependent phosphate transport protein 2A |
| NCBI Synonym Full Names: | solute carrier family 34 (type II sodium/phosphate cotransporter), member 1 |
| NCBI Official Symbol: | SLC34A1 |
| NCBI Official Synonym Symbols: | NPT2; FRTS2; SLC11; NAPI-3; NPTIIa; NPHLOP1; SLC17A2 |
| NCBI Protein Information: | sodium-dependent phosphate transport protein 2A; naPi-2a; Na(+)/Pi cotransporter 2A; sodium/phosphate co-transporter; sodium/phosphate cotransporter 2A; solute carrier family 34 member 1; Na+-phosphate cotransporter type II; sodium-phosphate transport protein 2A; Na(+)-dependent phosphate cotransporter 2A; renal sodium-dependent phosphate transporter; solute carrier family 17 (sodium phosphate), member 2; solute carrier family 34 (sodium phosphate), member 1 |
| UniProt Protein Name: | Sodium-dependent phosphate transport protein 2A |
| UniProt Synonym Protein Names: | Na(+)-dependent phosphate cotransporter 2A; NaPi-3; Sodium/phosphate cotransporter 2A; Na(+)/Pi cotransporter 2A; NaPi-2a; Solute carrier family 34 member 1 |
| Protein Family: | Sodium-dependent phosphate transport protein |
| UniProt Gene Name: | SLC34A1 |
| UniProt Entry Name: | NPT2A_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SLC34A1 antibody (CAB13635) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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