Anti-SLC28A3 Antibody (CAB10320)

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SKU:
CAB10320
Product type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
Frequently bought together:

Description

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Antibody Name:Anti-SLC28A3 Antibody
Antibody SKU:CAB10320
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 612-691 of human SLC28A3 (NP_071410.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:HepG2, 293T
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 612-691 of human SLC28A3 (NP_071410.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LSST PVDI NCHH VLEN AFNS TFPG NTTK VIAC CQSL LSST VAKG PGEV IPGG NHSL YSLK GCCT LLNP STFN CNGI SNTF
Gene ID:64078
Uniprot:Q9HAS3
Cellular Location:Cell membrane, Endoplasmic reticulum membrane, Multi-pass membrane protein
Calculated MW:69kDa/76kDa
Observed MW:77kDa
Synonyms:SLC28A3, CNT3
Background:
UniProt Protein Function:SLC28A3: Sodium-dependent, pyrimidine- and purine-selective. Involved in the homeostasis of endogenous nucleosides. Exhibits the transport characteristics of the nucleoside transport system cib or N3 subtype (N3/cib) (with marked transport of both thymidine and inosine). Employs a 2:1 sodium/nucleoside ratio. Also able to transport gemcitabine, 3'-azido-3'-deoxythymidine (AZT), ribavirin and 3-deazauridine. Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
UniProt Protein Details:

Protein type:Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family

Chromosomal Location of Human Ortholog: 9q21.32-q21.33

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function:nucleoside:sodium symporter activity; purine-specific nucleoside:sodium symporter activity; pyrimidine- and adenine-specific:sodium symporter activity

Biological Process: pyrimidine nucleoside transport

NCBI Summary:Nucleoside transporters, such as SLC28A3, regulate multiple cellular processes, including neurotransmission, vascular tone, adenosine concentration in the vicinity of cell surface receptors, and transport and metabolism of nucleoside drugs. SLC28A3 shows broad specificity for pyrimidine and purine nucleosides (Ritzel et al., 2001 [PubMed 11032837]).[supplied by OMIM, Mar 2008]
UniProt Code:Q9HAS3
NCBI GenInfo Identifier:74752767
NCBI Gene ID:64078
NCBI Accession:Q9HAS3.1
UniProt Secondary Accession:Q9HAS3,A8K9Y4, B1AML0, B2RA51, B4E2S8, F5GYE3,
UniProt Related Accession:Q9HAS3
Molecular Weight:77kDa
NCBI Full Name:Solute carrier family 28 member 3
NCBI Synonym Full Names:solute carrier family 28 member 3
NCBI Official Symbol:SLC28A3  
NCBI Official Synonym Symbols:CNT3  
NCBI Protein Information:solute carrier family 28 member 3
UniProt Protein Name:Solute carrier family 28 member 3
UniProt Synonym Protein Names:Concentrative Na(+)-nucleoside cotransporter 3; CNT 3; hCNT3
Protein Family:Solute carrier family
UniProt Gene Name:SLC28A3  
Anti-SLC28A3 Antibody (CAB10320)Western blot analysis of extracts of various cell lines, using SLC28A3 antibody (CAB10320) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.

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