Anti-SLC25A20 Antibody (CAB13956)
- SKU:
- CAB13956
- Product type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| Antibody Name: | Anti-SLC25A20 Antibody |
| Antibody SKU: | CAB13956 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-301 of human SLC25A20 (NP_000378.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-301 of human SLC25A20 (NP_000378.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MADQ PKPI SPLK NLLA GGFG GVCL VFVG HPLD TVKV RLQT QPPS LPGQ PPMY SGTF DCFR KTLF REGI TGLY RGMA APII GVTP MFAV CFFG FGLG KKLQ QKHP EDVL SYPQ LFAA GMLS GVFT TGIM TPGE RIKC LLQI QASS GESK YTGT LDCA KKLY QEFG IRGI YKGT VLTL MRDV PASG MYFM TYEW LKNI FTPE GKRV SELS APRI LVAG GIAG IFNW AVAI PPDV LKSR FQTA PPGK YPNG FRDV LREL IRDE GVTS LYKG FNAV MIRA FPAN AACF LGFE VAMK FLNW ATPN L |
| Gene ID: | 788 |
| Uniprot: | O43772 |
| Cellular Location: | Mitochondrion inner membrane, Multi-pass membrane protein |
| Calculated MW: | 32kDa |
| Observed MW: | 39kDa |
| Synonyms: | SLC25A20, CAC, CACT |
| Background: | This gene product is one of several closely related mitochondrial-membrane carrier proteins that shuttle substrates between cytosol and the intramitochondrial matrix space. This protein mediates the transport of acylcarnitines into mitochondrial matrix for their oxidation by the mitochondrial fatty acid-oxidation pathway. Mutations in this gene are associated with carnitine-acylcarnitine translocase deficiency, which can cause a variety of pathological conditions such as hypoglycemia, cardiac arrest, hepatomegaly, hepatic dysfunction and muscle weakness, and is usually lethal in new born and infants. |
| UniProt Protein Function: | SLC25A20: Mediates the transport of acylcarnitines of different length across the mitochondrial inner membrane from the cytosol to the mitochondrial matrix for their oxidation by the mitochondrial fatty acid-oxidation pathway. Defects in SLC25A20 are the cause of carnitine- acylcarnitine translocase deficiency (CACT deficiency). It is an autosomal recessive deficiency in mitochondrial oxidation of fatty acids. It is usually lethal within a few hours or days after birth. Symptoms characterizing its normally severe clinical phenotype include fatty hepatomegaly with abnormal liver function, cardiomyopathy, muscle weakness and episodes of life-threatening coma, which eventually lead to death. Belongs to the mitochondrial carrier family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Transporter; Mitochondrial; Transporter, SLC family; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 3p21.31 Cellular Component: cytoplasm; mitochondrial inner membrane; mitochondrion Molecular Function:acyl carnitine transporter activity; structural constituent of ribosome Biological Process: carnitine shuttle; translation Disease: Carnitine-acylcarnitine Translocase Deficiency |
| NCBI Summary: | This gene product is one of several closely related mitochondrial-membrane carrier proteins that shuttle substrates between cytosol and the intramitochondrial matrix space. This protein mediates the transport of acylcarnitines into mitochondrial matrix for their oxidation by the mitochondrial fatty acid-oxidation pathway. Mutations in this gene are associated with carnitine-acylcarnitine translocase deficiency, which can cause a variety of pathological conditions such as hypoglycemia, cardiac arrest, hepatomegaly, hepatic dysfunction and muscle weakness, and is usually lethal in new born and infants. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O43772 |
| NCBI GenInfo Identifier: | 3914023 |
| NCBI Gene ID: | 788 |
| NCBI Accession: | O43772.1 |
| UniProt Secondary Accession: | O43772,Q9UIQ2, B2R7F4, |
| UniProt Related Accession: | O43772 |
| Molecular Weight: | 32,944 Da |
| NCBI Full Name: | Mitochondrial carnitine/acylcarnitine carrier protein |
| NCBI Synonym Full Names: | solute carrier family 25 member 20 |
| NCBI Official Symbol: | SLC25A20 |
| NCBI Official Synonym Symbols: | CAC; CACT |
| NCBI Protein Information: | mitochondrial carnitine/acylcarnitine carrier protein |
| UniProt Protein Name: | Mitochondrial carnitine/acylcarnitine carrier protein |
| UniProt Synonym Protein Names: | Carnitine/acylcarnitine translocase; CAC; Solute carrier family 25 member 20 |
| Protein Family: | Mitochondrial carnitine/acylcarnitine carrier protein |
| UniProt Gene Name: | SLC25A20 |
| UniProt Entry Name: | MCAT_HUMAN |
 | Western blot analysis of extracts of mouse liver, using SLC25A20 Antibody (CAB13956) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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