Anti-SLC23A2 Antibody (CAB6740)
- SKU:
- CAB6740
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| Antibody Name: | Anti-SLC23A2 Antibody |
| Antibody SKU: | CAB6740 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-90 of human SLC23A2 (NP_976072.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:10 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SKOV3, HepG2, Mouse brain, Mouse lung, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-90 of human SLC23A2 (NP_976072.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MMGI GKNT TSKS MEAG SSTE GKYE DEAK HPAF FTLP VVIN GGAT SSGE QDNE DTEL MAIY TTEN GIAE KSSL AETL DSTG SLDP QRSD MI |
| Gene ID: | 9962 |
| Uniprot: | Q9UGH3 |
| Cellular Location: | Cell membrane, Multi-pass membrane protein |
| Calculated MW: | 58kDa/70kDa |
| Observed MW: | 70kDa |
| Synonyms: | SLC23A2, NBTL1, SLC23A1, SVCT2, YSPL2, hSVCT2 |
| Background: | The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two required transporters and the encoded protein accounts for tissue-specific uptake of vitamin C. Previously, this gene had an official symbol of SLC23A1. |
| UniProt Protein Function: | SLC23A2: Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate. Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily. |
| UniProt Protein Details: | Protein type:Transporter; Membrane protein, integral; Transporter, SLC family; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 20p13 Cellular Component: membrane; basolateral plasma membrane; integral to plasma membrane; apical plasma membrane; cytoplasm; integral to membrane; plasma membrane; basal plasma membrane Molecular Function:L-ascorbate:sodium symporter activity; sodium-dependent multivitamin transmembrane transporter activity; L-ascorbic acid transporter activity; nucleobase transmembrane transporter activity Biological Process: vitamin metabolic process; molecular hydrogen transport; sodium ion transport; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; L-ascorbic acid metabolic process; nucleobase transport; response to oxidative stress; water-soluble vitamin metabolic process; L-ascorbic acid transport |
| NCBI Summary: | The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two required transporters and the encoded protein accounts for tissue-specific uptake of vitamin C. Previously, this gene had an official symbol of SLC23A1. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UGH3 |
| NCBI GenInfo Identifier: | 24212469 |
| NCBI Gene ID: | 9962 |
| NCBI Accession: | Q9UGH3.1 |
| UniProt Secondary Accession: | Q9UGH3,Q8WWR4, Q92512, Q96D54, Q9UNU1, Q9UP85, B4DJZ1 |
| UniProt Related Accession: | Q9UGH3 |
| Molecular Weight: | Observed MW: 70kDaCalculated MW: 58kDa/70kDa |
| NCBI Full Name: | Solute carrier family 23 member 2 |
| NCBI Synonym Full Names: | solute carrier family 23 (ascorbic acid transporter), member 2 |
| NCBI Official Symbol: | SLC23A2 |
| NCBI Official Synonym Symbols: | NBTL1; SVCT2; YSPL2; SLC23A1 |
| NCBI Protein Information: | solute carrier family 23 member 2; hSVCT2; yolk sac permease-like molecule 2; Na(+)/L-ascorbic acid transporter 2; nucleobase transporter-like 1 protein; sodium-dependent vitamin C transporter-2; solute carrier family 23 (nucleobase transporters), member 1; solute carrier family 23 (nucleobase transporters), member 2 |
| UniProt Protein Name: | Solute carrier family 23 member 2 |
| UniProt Synonym Protein Names: | Na(+)/L-ascorbic acid transporter 2; Nucleobase transporter-like 1 protein; Sodium-dependent vitamin C transporter 2; hSVCT2; Yolk sac permease-like molecule 2 |
| Protein Family: | Solute carrier family |
| UniProt Gene Name: | SLC23A2 |
| UniProt Entry Name: | S23A2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SLC23A2 antibody (CAB6740) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunofluorescence analysis of MCF7 cells using SLC23A2 antibody (CAB6740). |
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