Anti-SLC22A8 Antibody (CAB14575)

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SKU:
CAB14575
Product type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
Frequently bought together:

Description

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Antibody Name:Anti-SLC22A8 Antibody
Antibody SKU:CAB14575
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 400 to the C-terminus of human SLC22A8 (NP_004245.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:22Rv1, Mouse kidney, Rat brain, Rat kidney
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 400 to the C-terminus of human SLC22A8 (NP_004245.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LTFV PLDL QTVR TVLA VFGK GCLS SSFS CLFL YTSE LYPT VIRQ TGMG VSNL WTRV GSMV SPLV KITG EVQP FIPN IIYG ITAL LGGS AALF LPET LNQP LPET IEDL ENWS LRAK KPKQ EPEV EKAS QRIP LQPH GPGL GSS
Gene ID:9376
Uniprot:Q8TCC7
Cellular Location:Basolateral cell membrane, Multi-pass membrane protein
Calculated MW:11kDa/46kDa/49kDa/59kDa/60kDa
Observed MW:70kDa
Synonyms:SLC22A8, OAT3
Background:This gene encodes a protein involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.
UniProt Protein Function:SLC22A8: Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenadine. Transports benzylpenicillin (PCG), estrone- 3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA). Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Transporter; Transporter, SLC family; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q11

Cellular Component: basolateral plasma membrane; plasma membrane; integral to membrane

Molecular Function:protein kinase C binding; inorganic anion exchanger activity; organic anion transmembrane transporter activity; quaternary ammonium group transmembrane transporter activity

Biological Process: quaternary ammonium group transport; response to toxin; response to methotrexate; transmembrane transport

NCBI Summary:This gene encodes a protein involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, May 2010]
UniProt Code:Q8TCC7
NCBI GenInfo Identifier:74730587
NCBI Gene ID:9376
NCBI Accession:Q8TCC7.1
UniProt Secondary Accession:Q8TCC7,O95820, Q59EW9, Q96TC1, B4DPH7, F5GWA8, F5H5J1
UniProt Related Accession:Q8TCC7
Molecular Weight:542
NCBI Full Name:Solute carrier family 22 member 8
NCBI Synonym Full Names:solute carrier family 22 (organic anion transporter), member 8
NCBI Official Symbol:SLC22A8  
NCBI Official Synonym Symbols:OAT3  
NCBI Protein Information:solute carrier family 22 member 8; hOAT3; organic anion transporter 3
UniProt Protein Name:Solute carrier family 22 member 8
UniProt Synonym Protein Names:Organic anion transporter 3; hOAT3
Protein Family:Solute carrier family
UniProt Gene Name:SLC22A8  
UniProt Entry Name:S22A8_HUMAN
Anti-SLC22A8 Antibody (CAB14575)Western blot analysis of extracts of various cell lines, using SLC22A8 antibody (CAB14575) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.

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