Anti-SLC22A8 Antibody (CAB14575)
- SKU:
- CAB14575
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-SLC22A8 Antibody |
| Antibody SKU: | CAB14575 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 400 to the C-terminus of human SLC22A8 (NP_004245.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 22Rv1, Mouse kidney, Rat brain, Rat kidney |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 400 to the C-terminus of human SLC22A8 (NP_004245.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LTFV PLDL QTVR TVLA VFGK GCLS SSFS CLFL YTSE LYPT VIRQ TGMG VSNL WTRV GSMV SPLV KITG EVQP FIPN IIYG ITAL LGGS AALF LPET LNQP LPET IEDL ENWS LRAK KPKQ EPEV EKAS QRIP LQPH GPGL GSS |
| Gene ID: | 9376 |
| Uniprot: | Q8TCC7 |
| Cellular Location: | Basolateral cell membrane, Multi-pass membrane protein |
| Calculated MW: | 11kDa/46kDa/49kDa/59kDa/60kDa |
| Observed MW: | 70kDa |
| Synonyms: | SLC22A8, OAT3 |
| Background: | This gene encodes a protein involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. |
| UniProt Protein Function: | SLC22A8: Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenadine. Transports benzylpenicillin (PCG), estrone- 3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA). Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transporter; Transporter, SLC family; Membrane protein, multi-pass; Membrane protein, integral Chromosomal Location of Human Ortholog: 11q11 Cellular Component: basolateral plasma membrane; plasma membrane; integral to membrane Molecular Function:protein kinase C binding; inorganic anion exchanger activity; organic anion transmembrane transporter activity; quaternary ammonium group transmembrane transporter activity Biological Process: quaternary ammonium group transport; response to toxin; response to methotrexate; transmembrane transport |
| NCBI Summary: | This gene encodes a protein involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, May 2010] |
| UniProt Code: | Q8TCC7 |
| NCBI GenInfo Identifier: | 74730587 |
| NCBI Gene ID: | 9376 |
| NCBI Accession: | Q8TCC7.1 |
| UniProt Secondary Accession: | Q8TCC7,O95820, Q59EW9, Q96TC1, B4DPH7, F5GWA8, F5H5J1 |
| UniProt Related Accession: | Q8TCC7 |
| Molecular Weight: | 542 |
| NCBI Full Name: | Solute carrier family 22 member 8 |
| NCBI Synonym Full Names: | solute carrier family 22 (organic anion transporter), member 8 |
| NCBI Official Symbol: | SLC22A8 |
| NCBI Official Synonym Symbols: | OAT3 |
| NCBI Protein Information: | solute carrier family 22 member 8; hOAT3; organic anion transporter 3 |
| UniProt Protein Name: | Solute carrier family 22 member 8 |
| UniProt Synonym Protein Names: | Organic anion transporter 3; hOAT3 |
| Protein Family: | Solute carrier family |
| UniProt Gene Name: | SLC22A8 |
| UniProt Entry Name: | S22A8_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SLC22A8 antibody (CAB14575) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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