Anti-SLC22A5 Antibody (CAB1676)

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SKU:
CAB1676
Product type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction
Frequently bought together:

Description

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Antibody Name:Anti-SLC22A5 Antibody
Antibody SKU:CAB1676
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human SLC22A5 (NP_003051.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:MCF7, OVCAR3, A-549, DU145, SW480, Mouse intestine, Mouse kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human SLC22A5 (NP_003051.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MRDY DEVT AFLG EWGP FQRL IFFL LSAS IIPN GFTG LSSV FLIA TPEH RCRV PDAA NLSS AWRN HTVP LRLR DGRE VPHS CRRY RLAT IANF SALG LEPG RDVD LGQL EQES CLDG WEFS QDVY LSTI VTEW NLVC EDDW KAPL TISL FFVG VLLG SFIS GQLS DRFG RKNV LFVT MGMQ
Gene ID:6584
Uniprot:O76082
Cellular Location:Membrane, Multi-pass membrane protein
Calculated MW:24kDa/62kDa/65kDa
Observed MW:70kDa
Synonyms:SLC22A5, CDSP, OCTN2
Background:Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is a plasma integral membrane protein which functions both as an organic cation transporter and as a sodium-dependent high affinity carnitine transporter. The encoded protein is involved in the active cellular uptake of carnitine. Mutations in this gene are the cause of systemic primary carnitine deficiency (CDSP), an autosomal recessive disorder manifested early in life by hypoketotic hypoglycemia and acute metabolic decompensation, and later in life by skeletal myopathy or cardiomyopathy. Alternative splicing of this gene results in multiple transcript variants.
UniProt Protein Function:SLC22A5: Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3. Defects in SLC22A5 are the cause of systemic primary carnitine deficiency (CDSP). CDSP is an autosomal recessive disorder of fatty acid oxidation caused by defective carnitine transport. Present early in life with hypoketotic hypoglycemia and acute metabolic decompensation, or later in life with skeletal myopathy or cardiomyopathy. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Transporter, SLC family; Membrane protein, multi-pass; Membrane protein, integral; Transporter

Chromosomal Location of Human Ortholog: 5q23.3

Cellular Component: brush border membrane; basolateral plasma membrane; apical plasma membrane; plasma membrane; integral to membrane

Molecular Function:protein binding; antibiotic transporter activity; symporter activity; carnitine transporter activity; drug transporter activity; quaternary ammonium group transmembrane transporter activity; ATP binding; PDZ domain binding

Biological Process: quaternary ammonium group transport; drug transport; antibiotic transport; sodium ion transport; multidrug transport; transmembrane transport; carnitine transport; quorum sensing during interaction with host

Disease: Carnitine Deficiency, Systemic Primary

NCBI Summary:Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is a plasma integral membrane protein which functions both as an organic cation transporter and as a sodium-dependent high affinity carnitine transporter. The encoded protein is involved in the active cellular uptake of carnitine. Mutations in this gene are the cause of systemic primary carnitine deficiency (CDSP), an autosomal recessive disorder manifested early in life by hypoketotic hypoglycemia and acute metabolic decompensation, and later in life by skeletal myopathy or cardiomyopathy. [provided by RefSeq, Jul 2008]
UniProt Code:O76082
NCBI GenInfo Identifier:8928257
NCBI Gene ID:6584
NCBI Accession:O76082.1
UniProt Secondary Accession:O76082,Q6ZQZ8, Q96EH6, A2Q0V1, B2R844, D3DQ87,
UniProt Related Accession:O76082
Molecular Weight:557
NCBI Full Name:Solute carrier family 22 member 5
NCBI Synonym Full Names:solute carrier family 22 (organic cation/carnitine transporter), member 5
NCBI Official Symbol:SLC22A5  
NCBI Official Synonym Symbols:CDSP; OCTN2; OCTN2VT  
NCBI Protein Information:solute carrier family 22 member 5; organic cation/carnitine transporter 2; high-affinity sodium dependent carnitine cotransporter
UniProt Protein Name:Solute carrier family 22 member 5
UniProt Synonym Protein Names:High-affinity sodium-dependent carnitine cotransporter; Organic cation/carnitine transporter 2
Protein Family:Solute carrier family
UniProt Gene Name:SLC22A5  
UniProt Entry Name:S22A5_HUMAN
Anti-SLC22A5 Antibody (CAB1676)Western blot analysis of extracts of various cell lines, using SLC22A5 antibody (CAB1676) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.
Anti-SLC22A5 Antibody (CAB1676)Immunofluorescence analysis of MCF-7 cells using SLC22A5 antibody (CAB1676). Blue: DAPI for nuclear staining.

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