Anti-SLC22A4 Antibody (CAB10490)
- SKU:
- CAB10490
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| Antibody Name: | Anti-SLC22A4 Antibody |
| Antibody SKU: | CAB10490 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 42-141 of human SLC22A4 (NP_003050.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:1000 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SW480, HL-60, NCI-H460, LO2, HeLa, Mouse kidney, Mouse liver, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 42-141 of human SLC22A4 (NP_003050.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LAGT PEHR CRVP DAAN LSSA WRNN SVPL RLRD GREV PHSC SRYR LATI ANFS ALGL EPGR DVDL GQLE QESC LDGW EFSQ DVYL STVV TEWN LVCE DNWK |
| Gene ID: | 6583 |
| Uniprot: | Q9H015 |
| Cellular Location: | Membrane, Multi-pass membrane protein |
| Calculated MW: | 62kDa |
| Observed MW: | 62kDa |
| Synonyms: | SLC22A4, DFNB60, OCTN1 |
| Background: | Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is an organic cation transporter and plasma integral membrane protein containing eleven putative transmembrane domains as well as a nucleotide-binding site motif. Transport by this protein is at least partially ATP-dependent. |
| UniProt Protein Function: | SLC22A4: Sodium-ion dependent, low affinity carnitine transporter. Probably transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 1.78. A key substrate of this transporter seems to be ergothioneine (ET). Genetic variations in SLC22A4 are a cause of susceptibility to rheumatoid arthritis (RA). It is a systemic inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Transporter; Transporter, SLC family Chromosomal Location of Human Ortholog: 5q31.1 Cellular Component: apical plasma membrane; integral to plasma membrane; mitochondrion; plasma membrane Molecular Function:carnitine transporter activity; cation:cation antiporter activity; nucleotide binding; organic anion transmembrane transporter activity; PDZ domain binding; protein binding; quaternary ammonium group transmembrane transporter activity; secondary active organic cation transmembrane transporter activity Biological Process: body fluid secretion; carnitine metabolic process; carnitine transport; organic cation transport; quaternary ammonium group transport Disease: Rheumatoid Arthritis |
| NCBI Summary: | Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is an organic cation transporter and plasma integral membrane protein containing eleven putative transmembrane domains as well as a nucleotide-binding site motif. Transport by this protein is at least partially ATP-dependent. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9H015 |
| NCBI GenInfo Identifier: | 146345508 |
| NCBI Gene ID: | 6583 |
| NCBI Accession: | Q9H015.3 |
| UniProt Secondary Accession: | Q9H015,O14546, |
| UniProt Related Accession: | Q9H015 |
| Molecular Weight: | 62kDa |
| NCBI Full Name: | Solute carrier family 22 member 4 |
| NCBI Synonym Full Names: | solute carrier family 22 member 4 |
| NCBI Official Symbol: | SLC22A4 |
| NCBI Official Synonym Symbols: | OCTN1; DFNB60 |
| NCBI Protein Information: | solute carrier family 22 member 4 |
| UniProt Protein Name: | Solute carrier family 22 member 4 |
| UniProt Synonym Protein Names: | Ergothioneine transporter; ET transporter; Organic cation/carnitine transporter 1 |
| Protein Family: | Solute carrier family |
| UniProt Gene Name: | SLC22A4 |
 | Western blot analysis of extracts of various cell lines, using SLC22A4 antibody (CAB10490) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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