Anti-SLC22A11 Antibody (CAB7816)
- SKU:
- CAB7816
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| Antibody Name: | Anti-SLC22A11 Antibody |
| Antibody SKU: | CAB7816 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 40-150 of human SLC22A11 (NP_060954.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SW620, BT-474, HepG2, 293T, Mouse kidney, Mouse liver, Rat kidney, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 40-150 of human SLC22A11 (NP_060954.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | FSAA IPGH RCWT HMLD NGSA VSTN MTPK ALLT ISIP PGPN QGPH QCRR FRQP QWQL LDPN ATAT SWSE ADTE PCVD GWVY DRSV FTST IVAK WDLV CSSQ GLKP LSQS IFM |
| Gene ID: | 55867 |
| Uniprot: | Q9NSA0 |
| Cellular Location: | Cell membrane, Multi-pass membrane protein |
| Calculated MW: | 48kDa/59kDa |
| Observed MW: | 75kDa |
| Synonyms: | SLC22A11, OAT4, hOAT4 |
| Background: | The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and is found mainly in the kidney and in the placenta, where it may act to prevent potentially harmful organic anions from reaching the fetus. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | SLC22A11: Mediates saturable uptake of estrone sulfate, dehydroepiandrosterone sulfate and related compounds. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Transporter; Membrane protein, multi-pass; Cell surface; Transporter, SLC family Chromosomal Location of Human Ortholog: 11q13.1 Cellular Component: integral to plasma membrane; apical plasma membrane; plasma membrane; external side of plasma membrane Molecular Function:protein binding; inorganic anion exchanger activity; organic anion transmembrane transporter activity; sodium-independent organic anion transmembrane transporter activity Biological Process: urate metabolic process; transmembrane transport; organic anion transport |
| NCBI Summary: | The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and is found mainly in the kidney and in the placenta, where it may act to prevent potentially harmful organic anions from reaching the fetus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015] |
| UniProt Code: | Q9NSA0 |
| NCBI GenInfo Identifier: | 808175981 |
| NCBI Gene ID: | 55867 |
| NCBI Accession: | NP_001294914.1 |
| UniProt Secondary Accession: | Q9NSA0,Q53GR2, Q6ZP72, Q8NBU4, A8K426, |
| UniProt Related Accession: | Q9NSA0 |
| Molecular Weight: | 60 kDa (MW of target protein) |
| NCBI Full Name: | solute carrier family 22 member 11 isoform 2 |
| NCBI Synonym Full Names: | solute carrier family 22 (organic anion/urate transporter), member 11 |
| NCBI Official Symbol: | SLC22A11 |
| NCBI Official Synonym Symbols: | OAT4; hOAT4 |
| NCBI Protein Information: | solute carrier family 22 member 11 |
| UniProt Protein Name: | Solute carrier family 22 member 11 |
| UniProt Synonym Protein Names: | Organic anion transporter 4 |
| Protein Family: | Solute carrier family |
| UniProt Gene Name: | SLC22A11 |
| UniProt Entry Name: | S22AB_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SLC22A11 antibody (CAB7816) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Basic Kit (RM00020)._Exposure time: 30s. |
 | Immunofluorescence analysis of A549 cells using SLC22A11 antibody (CAB7816). Blue: DAPI for nuclear staining. |
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