Anti-SLC13A3 Antibody (CAB15183)
- SKU:
- CAB15183
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| Antibody Name: | Anti-SLC13A3 Antibody |
| Antibody SKU: | CAB15183 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 160-240 of human SLC13A3 (NP_073740.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | U-251MG, 293T |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 160-240 of human SLC13A3 (NP_073740.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | KSLF GQKE VRKD PSQE SEEN TAAV RRNG LHTV PTEM QFLA STEA KDHP GETE VPLD LPAD SRKE DEYR RNIW KGFL ISIP Y |
| Gene ID: | 64849 |
| Uniprot: | Q8WWT9 |
| Cellular Location: | Cell membrane, Multi-pass membrane protein |
| Calculated MW: | 25kDa/37kDa/57kDa/61kDa/66kDa |
| Observed MW: | 65kDa |
| Synonyms: | SLC13A3, NADC3, SDCT2 |
| Background: | Mammalian sodium-dicarboxylate cotransporters transport succinate and other Krebs cycle intermediates. They fall into 2 categories based on their substrate affinity: low affinity and high affinity. Both the low- and high-affinity transporters play an important role in the handling of citrate by the kidneys. The protein encoded by this gene represents the high-affinity form. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been characterized yet. |
| UniProt Protein Function: | Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. |
| NCBI Summary: | Mammalian sodium-dicarboxylate cotransporters transport succinate and other Krebs cycle intermediates. They fall into 2 categories based on their substrate affinity: low affinity and high affinity. Both the low- and high-affinity transporters play an important role in the handling of citrate by the kidneys. The protein encoded by this gene represents the high-affinity form. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been characterized yet. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8WWT9 |
| NCBI GenInfo Identifier: | 301069353 |
| NCBI Gene ID: | 64849 |
| NCBI Accession: | NP_073740 |
| UniProt Secondary Accession: | Q8WWT9,Q8WWT9, |
| UniProt Related Accession: | Q8WWT9 |
| Molecular Weight: | 67kDa |
| NCBI Full Name: | solute carrier family 13 member 3 isoform e |
| NCBI Synonym Full Names: | solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 |
| NCBI Official Symbol: | SLC13A3 |
| NCBI Official Synonym Symbols: | NADC3; SDCT2 |
| NCBI Protein Information: | solute carrier family 13 member 3; Na(+)/dicarboxylate cotransporter 3; hNaDC3; naDC-3; sodium-dependent high affinity dicarboxylate transporter 3; sodium-dependent high-affinity dicarboxylate transporter 2 |
| UniProt Protein Name: | Slit homolog 1 protein |
| UniProt Synonym Protein Names: | Multiple epidermal growth factor-like domains protein 4; Multiple EGF-like domains protein 4 |
| Protein Family: | Slit homolog 1 protein |
| UniProt Gene Name: | SLIT1 |
 | Western blot analysis of extracts of various cell lines, using SLC13A3 antibody (CAB15183) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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