Anti-SLC12A7 Antibody (CAB12299)
- SKU:
- CAB12299
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| Antibody Name: | Anti-SLC12A7 Antibody |
| Antibody SKU: | CAB12299 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-70 of human SLC12A7 (NP_006589.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse kidney, Mouse liver, Rat kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-70 of human SLC12A7 (NP_006589.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MPTN FTVV PVEA HADG GGDE TAER TEAP GTPE GPEP ERPS PGDG NPRE NSPF LNNV EVEQ ESFF EGKN MA |
| Gene ID: | 10723 |
| Uniprot: | Q9Y666 |
| Cellular Location: | Cell membrane, Multi-pass membrane protein |
| Calculated MW: | 28kDa/119kDa |
| Observed MW: | 119kDa |
| Synonyms: | SLC12A7, KCC4 |
| Background: |
| UniProt Protein Function: | KCC4: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification. Belongs to the SLC12A transporter family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Chromosomal Location of Human Ortholog: 5p15.33 Cellular Component: plasma membrane Molecular Function:potassium ion symporter activity; potassium:chloride symporter activity; protein kinase binding Biological Process: ion transport; synaptic transmission; transport |
| UniProt Code: | Q9Y666 |
| NCBI GenInfo Identifier: | 166202480 |
| NCBI Gene ID: | 10723 |
| NCBI Accession: | Q9Y666.3 |
| UniProt Secondary Accession: | Q9Y666,Q4G0F3, Q96I81, Q9H7I3, Q9H7I7, Q9UFW2, A6NDS8 |
| UniProt Related Accession: | Q9Y666 |
| Molecular Weight: | Calculated MW: 28kDa/119kDaObserved MW: 119kDa |
| NCBI Full Name: | Solute carrier family 12 member 7 |
| NCBI Synonym Full Names: | solute carrier family 12 member 7 |
| NCBI Official Symbol: | SLC12A7 |
| NCBI Official Synonym Symbols: | KCC4 |
| NCBI Protein Information: | solute carrier family 12 member 7 |
| UniProt Protein Name: | Solute carrier family 12 member 7 |
| UniProt Synonym Protein Names: | Electroneutral potassium-chloride cotransporter 4; K-Cl cotransporter 4 |
| Protein Family: | Solute carrier family |
| UniProt Gene Name: | SLC12A7 |
 | Western blot analysis of extracts of various cell lines, using SLC12A7 antibody (CAB12299) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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