Anti-SLC12A3 Antibody (CAB18382)
- SKU:
- CAB18382
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
Frequently bought together:
Description
| Antibody Name: | Anti-SLC12A3 Antibody |
| Antibody SKU: | CAB18382 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human SLC12A3. |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: |
| Immunogen: | Recombinant protein of human SLC12A3. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 6559 |
| Uniprot: | P55017 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | Refer to figures |
| Synonyms: | NCC, NCCT, TSC, SLC12A3 |
| Background: |
| UniProt Protein Function: | NCCT: Key mediator of sodium and chloride reabsorption in this nephron segment, accounting for a significant fraction of renal sodium reabsorption. Interacts with KLHL3. Predominant in kidney. Activated by WNK3. Belongs to the SLC12A transporter family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transporter, SLC family; Membrane protein, integral; Transporter; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 16q13 Cellular Component: membrane; integral to plasma membrane; apical plasma membrane; plasma membrane; cytosol Molecular Function:protein binding; transporter activity; sodium:chloride symporter activity Biological Process: transport; sodium ion transport; chloride transport; ion transport; transmembrane transport Disease: Gitelman Syndrome |
| NCBI Summary: | This gene encodes a renal thiazide-sensitive sodium-chloride cotransporter that is important for electrolyte homeostasis. This cotransporter mediates sodium and chloride reabsorption in the distal convoluted tubule. Mutations in this gene cause Gitelman syndrome, a disease similar to Bartter's syndrome, that is characterized by hypokalemic alkalosis combined with hypomagnesemia, low urinary calcium, and increased renin activity associated with normal blood pressure. This cotransporter is the target for thiazide diuretics that are used for treating high blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P55017 |
| NCBI GenInfo Identifier: | 313104194 |
| NCBI Gene ID: | 6559 |
| NCBI Accession: | P55017.3 |
| UniProt Secondary Accession: | P55017,A8MSJ2, C9JNN9, |
| UniProt Related Accession: | P55017 |
| Molecular Weight: | 113,808 Da |
| NCBI Full Name: | Solute carrier family 12 member 3 |
| NCBI Synonym Full Names: | solute carrier family 12 (sodium/chloride transporter), member 3 |
| NCBI Official Symbol: | SLC12A3 |
| NCBI Official Synonym Symbols: | NCC; TSC; NCCT |
| NCBI Protein Information: | solute carrier family 12 member 3; Na-Cl symporter; Na-Cl cotransporter; thiazide-sensitive Na-Cl cotransporter; thiazide-sensitive sodium-chloride cotransporter; NaCl electroneutral thiazide-sensitive cotransporter |
| UniProt Protein Name: | Solute carrier family 12 member 3 |
| UniProt Synonym Protein Names: | Na-Cl cotransporter; NCC; Na-Cl symporter; Thiazide-sensitive sodium-chloride cotransporter |
| UniProt Gene Name: | SLC12A3 |
| UniProt Entry Name: | S12A3_HUMAN |
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