Anti-SLA2 Antibody (CAB12818)
- SKU:
- CAB12818
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-SLA2 Antibody |
| Antibody SKU: | CAB12818 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human SLA2 (NP_115590.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | K-562, A-431, HT-29 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human SLA2 (NP_115590.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MGSL PSRR KSLP SPSL SSSV QGQG PVTM EAER SKAT AVAL GSFP AGGP AELS LRLG EPLT IVSE DGDW WTVL SEVS GREY NIPS VHVA KVSH GWLY EGLS REKA EELL LLPG NPGG AFLI RESQ TRRG SYSL SVRL SRPA SWDR IRHY RIHC LDNG WLYI |
| Gene ID: | 84174 |
| Uniprot: | Q9H6Q3 |
| Cellular Location: | Cell membrane, Cytoplasm, Cytoplasmic vesicle |
| Calculated MW: | 20kDa/23kDa/25kDa/28kDa |
| Observed MW: | 28kDa |
| Synonyms: | SLA2, C20orf156, MARS, SLAP-2, SLAP2 |
| Background: | This gene encodes a member of the SLAP family of adapter proteins. The encoded protein may play an important receptor-proximal role in downregulating T and B cell-mediated responses and inhibits antigen receptor-induced calcium mobilization. This protein interacts with Cas-Br-M (murine) ecotropic retroviral transforming sequence c. Two transcript variants encoding distinct isoforms have been identified for this gene. |
| UniProt Protein Function: | SLAP2: Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold; Vesicle Chromosomal Location of Human Ortholog: 20q11.23 Cellular Component: cytoplasm; plasma membrane Molecular Function:protein binding; protein N-terminus binding; SH3/SH2 adaptor activity Biological Process: antigen receptor-mediated signaling pathway; B cell mediated immunity; intracellular receptor-mediated signaling pathway; negative regulation of B cell activation; negative regulation of calcium-mediated signaling; negative regulation of transcription from RNA polymerase II promoter; T cell activation |
| NCBI Summary: | This gene encodes a member of the SLAP family of adapter proteins. The encoded protein may play an important receptor-proximal role in downregulating T and B cell-mediated responses and inhibits antigen receptor-induced calcium mobilization. This protein interacts with Cas-Br-M (murine) ecotropic retroviral transforming sequence c. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9H6Q3 |
| NCBI GenInfo Identifier: | 30173374 |
| NCBI Gene ID: | 84174 |
| NCBI Accession: | Q9H6Q3.3 |
| UniProt Secondary Accession: | Q9H6Q3,Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135, A8K648 E1P5U1, E1P5U2, |
| UniProt Related Accession: | Q9H6Q3 |
| Molecular Weight: | 20,380 Da |
| NCBI Full Name: | Src-like-adapter 2 |
| NCBI Synonym Full Names: | Src like adaptor 2 |
| NCBI Official Symbol: | SLA2 |
| NCBI Official Synonym Symbols: | MARS; SLAP2; SLAP-2; C20orf156 |
| NCBI Protein Information: | src-like-adapter 2 |
| UniProt Protein Name: | Src-like-adapter 2 |
| UniProt Synonym Protein Names: | Modulator of antigen receptor signaling; MARS; Src-like adapter protein 2; SLAP-2 |
| Protein Family: | Src-like-adapter |
| UniProt Gene Name: | SLA2 |
| UniProt Entry Name: | SLAP2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SLA2 antibody (CAB12818) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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