Anti-SIVA1 Antibody (CAB6326)

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SKU:
CAB6326
Product type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Death
Frequently bought together:

Description

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Antibody Name:Anti-SIVA1 Antibody
Antibody SKU:CAB6326
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-110 of human SIVA1 (NP_068355.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:MCF7, SW620
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-110 of human SIVA1 (NP_068355.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MPKR SCPF ADVA PLQL KVRV SQRE LSRG VCAE RYSQ EVFD PSGV ASIA CSSC VRAV DGKA VCGQ CERA LCGQ CVRT CWGC GSVA CTLC GLVD CSDM YEKV LCTS CAMF ET
Gene ID:10572
Uniprot:O15304
Cellular Location:Cytoplasm, Nucleus
Calculated MW:11kDa/18kDa
Observed MW:15kDa
Synonyms:SIVA1, CD27BP, SIVA, Siva-1, Siva-2
Background:This gene encodes a protein with an important role in the apoptotic (programmed cell death) pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. The CD27 antigen cytoplasmic tail binds to the N-terminus of this protein. Two alternatively spliced transcript variants encoding distinct proteins have been described.
UniProt Protein Function:Siva: a proapoptotic protein. Associates with CD27, a member of the tumor necrosis factor receptor family. Two alternatively spliced isoforms have been described. Isoform 1 but not isoform 2 may induce TNFRSF7/CD27 mediated apoptosis. Isoform 1 inhibits Bcl-xL anti-apoptotic activity.
UniProt Protein Details:

Protein type:Apoptosis

Chromosomal Location of Human Ortholog: 14q32.33

Cellular Component: nucleoplasm; mitochondrion; cytoplasm; nucleus

Molecular Function:viral receptor activity; protein binding; zinc ion binding; metal ion binding; CD27 receptor binding

Biological Process: entry of virus into host cell; inhibition of NF-kappaB transcription factor; activated T cell apoptosis

NCBI Summary:This gene encodes a protein with an important role in the apoptotic (programmed cell death) pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. The CD27 antigen cytoplasmic tail binds to the N-terminus of this protein. Two alternatively spliced transcript variants encoding distinct proteins have been described. [provided by RefSeq, Jul 2008]
UniProt Code:O15304
NCBI GenInfo Identifier:31077008
NCBI Gene ID:10572
NCBI Accession:O15304.2
UniProt Secondary Accession:O15304,Q96P98, Q9UPD6,
UniProt Related Accession:O15304
Molecular Weight:175
NCBI Full Name:Apoptosis regulatory protein Siva
NCBI Synonym Full Names:SIVA1, apoptosis-inducing factor
NCBI Official Symbol:SIVA1  
NCBI Official Synonym Symbols:SIVA; CD27BP; Siva-1; Siva-2  
NCBI Protein Information:apoptosis regulatory protein Siva; CD27-binding (Siva) protein
UniProt Protein Name:Apoptosis regulatory protein Siva
UniProt Synonym Protein Names:CD27-binding protein; CD27BP
Protein Family:Apoptosis regulatory protein
UniProt Gene Name:SIVA1  
UniProt Entry Name:SIVA_HUMAN
Anti-SIVA1 Antibody (CAB6326)Western blot analysis of extracts of various cell lines, using SIVA1 antibody (CAB6326) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.

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