Anti-SHIP1 Antibody (CAB3571)

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SKU:
CAB3571
Product type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
SHIP
SHIP-1
SHIP1
SIP-145
hp51CN
p150Ship
Frequently bought together:

Description

Product Name:SHIP1 Rabbit mAb
Product Code:CAB3571
Size:20uL, 50uL, 100uL
Synonyms:SHIP, SHIP-1, SHIP1, SIP-145, hp51CN, p150Ship
Applications:WB, IHC, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human SHIP11
Applications:WB, IHC, IF
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:Raji, U-937
Immunogen:A synthesized peptide derived from human SHIP11
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:3635
Uniprot:Q92835
Cellular Location:Cytoplasm, Membrane, Peripheral membrane protein
Calculated MW:140kDa
Observed MW:145kDa
UniProt Protein Function:SHIP: an SH2-containing inositol phosphatase. A hemopoietic-specific phosphatase that regulates cell survival, growth, cell cycle arrest and apoptosis. Hydrolyzes Ins(1,3,4,5)P4 and PtdIns(3,4,5)P3. A cytosolic protein with a SH2 domain in its N-terminus and two NPXY Shc binding motifs at its C-terminus. Upon receptor cross-linking, SHIP is first recruited to the plasma membrane by its SH2, followed by tyrosine phosphorylation on the NPXY motif. Both membrane relocalization and phosphorylation are essential for its regulatory function. Associates with SHC after cytokine stimulation.
UniProt Protein Details:

Protein type:Phosphatase, lipid; EC 3.1.3.86; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 2q37.1

Cellular Component: cytoskeleton; cytosol; lipid raft; plasma membrane

Molecular Function:inositol-polyphosphate 5-phosphatase activity; protein binding; PTB domain binding; SH3 domain binding

Biological Process: apoptosis; blood coagulation; determination of adult life span; immunoglobulin mediated immune response; inositol phosphate metabolic process; leukocyte migration; negative regulation of B cell proliferation; negative regulation of bone resorption; negative regulation of immune response; negative regulation of interleukin-6 biosynthetic process; negative regulation of monocyte differentiation; negative regulation of neutrophil differentiation; negative regulation of osteoclast differentiation; negative regulation of signal transduction; phosphate metabolic process; phosphatidylinositol biosynthetic process; phosphoinositide dephosphorylation; phospholipid metabolic process; positive regulation of apoptosis; positive regulation of B cell differentiation; positive regulation of erythrocyte differentiation; signal transduction; T cell receptor signaling pathway

NCBI Summary:This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]
UniProt Code:Q92835
NCBI GenInfo Identifier:158564077
NCBI Gene ID:3635
NCBI Accession:Q92835.2
UniProt Secondary Accession:Q92835,O00145, Q13544, Q13545, Q6P5A4, Q92656, Q9UE80
UniProt Related Accession:Q92835
Molecular Weight:109,294 Da
NCBI Full Name:Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1
NCBI Synonym Full Names:inositol polyphosphate-5-phosphatase D
NCBI Official Symbol:INPP5D  
NCBI Official Synonym Symbols:SHIP; SHIP1; SHIP-1; hp51CN; SIP-145; p150Ship  
NCBI Protein Information:phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1
UniProt Protein Name:Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1
UniProt Synonym Protein Names:Inositol polyphosphate-5-phosphatase of 145 kDa; SIP-145; SH2 domain-containing inositol 5'-phosphatase 1; SH2 domain-containing inositol phosphatase 1; SHIP-1; p150Ship; hp51CN
Protein Family:Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase
UniProt Gene Name:INPP5D  
UniProt Entry Name:SHIP1_HUMAN

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