Anti-SGPL1 Antibody (CAB15745)
- SKU:
- CAB15745
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
| Antibody Name: | Anti-SGPL1 Antibody |
| Antibody SKU: | CAB15745 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 60-390 of human SGPL1 (NP_003892.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-87MG, LO2, 293T, A-431, Mouse liver, Mouse kidnay, Mouse lung, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 60-390 of human SGPL1 (NP_003892.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | VFQP ESLW SRFK KKCF KLTR KMPI IGRK IQDK LNKT KDDI SKNM SFLK VDKE YVKA LPSQ GLSS SAVL EKLK EYSS MDAF WQEG RASG TVYS GEEK LTEL LVKA YGDF AWSN PLHP DIFP GLRK IEAE IVRI ACSL FNGG PDSC GCVT SGGT ESIL MACK AYRD LAFE KGIK TPEI VAPQ SAHA AFNK AASY FGMK IVRV PLTK MMEV DVRA MRRA ISRN TAML VCST PQFP HGVI DPVP EVAK LAVK YKIP LHVD ACLG GFLI VFME KAGY PLEH PFDF RVKG VTSI SADT HKYG YAPK GSSL VLYS DKKY RNYQ FFVD TDWQ GGIY ASP |
| Gene ID: | 8879 |
| Uniprot: | O95470 |
| Cellular Location: | Endoplasmic reticulum membrane, Single-pass type III membrane protein |
| Calculated MW: | 63kDa |
| Observed MW: | 80kDa |
| Synonyms: | SGPL1, S1PL, SPL |
| Background: |
| UniProt Protein Function: | SGPL1: Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis. Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily. |
| UniProt Protein Details: | Protein type:Apoptosis; Lipid Metabolism - sphingolipid; EC 4.1.2.27; Lyase; Membrane protein, integral Chromosomal Location of Human Ortholog: 10q21 Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane Molecular Function:protein binding; sphinganine-1-phosphate aldolase activity Biological Process: ceramide metabolic process; fatty acid metabolic process; sphingolipid biosynthetic process; sphingolipid catabolic process |
| UniProt Code: | O95470 |
| NCBI GenInfo Identifier: | 37999486 |
| NCBI Gene ID: | 8879 |
| NCBI Accession: | O95470.3 |
| UniProt Secondary Accession: | O95470,Q7Z732, Q9ULG8, Q9UN89, B2RBD4, |
| UniProt Related Accession: | O95470 |
| Molecular Weight: | 63,524 Da |
| NCBI Full Name: | Sphingosine-1-phosphate lyase 1 |
| NCBI Synonym Full Names: | sphingosine-1-phosphate lyase 1 |
| NCBI Official Symbol: | SGPL1 |
| NCBI Official Synonym Symbols: | SPL; S1PL |
| NCBI Protein Information: | sphingosine-1-phosphate lyase 1 |
| UniProt Protein Name: | Sphingosine-1-phosphate lyase 1 |
| UniProt Synonym Protein Names: | Sphingosine-1-phosphate aldolase |
| Protein Family: | Sphingosine-1-phosphate lyase |
| UniProt Gene Name: | SGPL1 |
| UniProt Entry Name: | SGPL1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SGPL1 antibody (CAB15745) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 120s. |
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