| UniProt Protein Function: | SFRP2: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis. Belongs to the secreted frizzled-related protein (sFRP) family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 4q31.3 Cellular Component: extracellular matrix; extracellular space; integral to membrane Molecular Function:G-protein coupled receptor activity; integrin binding; Wnt-protein binding; Wnt receptor activity; fibronectin binding; receptor agonist activity Biological Process: convergent extension involved in axis elongation; collagen fibril organization; negative regulation of Wnt receptor signaling pathway; positive regulation of apoptosis; negative regulation of caspase activity; negative regulation of BMP signaling pathway; negative regulation of cell proliferation; cell-cell signaling; negative regulation of mesodermal cell fate specification; positive regulation of cell proliferation; negative regulation of cell migration; response to nutrient; negative regulation of epithelial cell proliferation; response to drug; negative regulation of JNK activity; negative regulation of peptidyl-tyrosine phosphorylation; male gonad development; positive regulation of cell adhesion mediated by integrin; digestive tract morphogenesis; chondrocyte development; positive regulation of peptidyl-serine phosphorylation; positive regulation of cell growth; patterning of blood vessels; positive regulation of osteoblast differentiation; positive regulation of angiogenesis; neural tube closure; cellular response to extracellular stimulus; positive regulation of fat cell differentiation; positive regulation of transcription from RNA polymerase II promoter; embryonic digit morphogenesis; negative regulation of cell growth; negative regulation of transcription, DNA-dependent |
| NCBI Summary: | This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q96HF1 |
| NCBI GenInfo Identifier: | 61216828 |
| NCBI Gene ID: | 6423 |
| NCBI Accession: | Q96HF1.2 |
| UniProt Secondary Accession: | Q96HF1,O14778, Q9HAP5, B3KQR2, |
| UniProt Related Accession: | Q96HF1 |
| Molecular Weight: | 295 |
| NCBI Full Name: | Secreted frizzled-related protein 2 |
| NCBI Synonym Full Names: | secreted frizzled-related protein 2 |
| NCBI Official Symbol: | SFRP2 |
| NCBI Official Synonym Symbols: | FRP-2; SARP1; SDF-5 |
| NCBI Protein Information: | secreted frizzled-related protein 2; SARP-1; sFRP-2; secreted apoptosis related protein 1; secreted apoptosis-related protein 1 |
| UniProt Protein Name: | Secreted frizzled-related protein 2 |
| UniProt Synonym Protein Names: | Secreted apoptosis-related protein 1; SARP-1 |
| Protein Family: | Secreted frizzled-related protein |
| UniProt Gene Name: | SFRP2 |
| UniProt Entry Name: | SFRP2_HUMAN |
