Anti-SETMAR Antibody (CAB6738)
- SKU:
- CAB6738
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| Antibody Name: | Anti-SETMAR Antibody |
| Antibody SKU: | CAB6738 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-300 of human SETMAR (NP_006506.3). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:20 - 1:50 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-300 of human SETMAR (NP_006506.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | KPEA PTEQ LDVA CGQE NLPV GAWP PGAA PAPF QYTP DHVV GPGA DIDP TQIT FPGC ICVK TPCL PGTC SCLR HGEN YDDN SCLR DIGS GGKY AEPV FECN VLCR CSDH CRNR VVQK GLQF HFQV FKTH KKGW GLRT LEFI PKGR FVCE YAGE VLGF SEVQ RRIH LQTK SDSN YIIA IREH VYNG QVME TFVD PTYI GNIG RFLN HSCE PNLL MIPV RIDS MVPK LALF AAKD IVPE EELS YDYS GRYL NLTV SEDK ERLD HGKL RKPC YCGA KSCT AFLP F |
| Gene ID: | 6419 |
| Uniprot: | Q53H47 |
| Cellular Location: | Chromosome, Nucleus |
| Calculated MW: | 40kDa/62kDa/78kDa |
| Observed MW: | Refer to Figures |
| Synonyms: | SETMAR, METNASE, Mar1 |
| Background: | This gene encodes a fusion protein that contains an N-terminal histone-lysine N-methyltransferase domain and a C-terminal mariner transposase domain. The encoded protein binds DNA and functions in DNA repair activities including non-homologous end joining and double strand break repair. The SET domain portion of this protein specifically methylates histone H3 lysines 4 and 36. This gene exists as a fusion gene only in anthropoid primates, other organisms lack mariner transposase domain. Alternate splicing results in multiple transcript variants. |
| UniProt Protein Function: | SETMAR: Histone methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3, 2 specific tags for epigenetic transcriptional activation. Specifically mediates dimethylation of H3 'Lys-36'. Has sequence-specific DNA-binding activity and recognizes the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element. Has DNA nicking activity. Has in vivo end joining activity and may mediate genomic integration of foreign DNA. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; Methyltransferase; Methyltransferase, protein lysine Chromosomal Location of Human Ortholog: 3p26.1 Cellular Component: condensed chromosome; nucleus Molecular Function:protein binding; structure-specific DNA binding; protein homodimerization activity; zinc ion binding; single-stranded DNA specific endodeoxyribonuclease activity; histone lysine N-methyltransferase activity (H3-K4 specific); endonuclease activity; double-stranded DNA binding; single-stranded DNA binding; transposase activity; histone lysine N-methyltransferase activity (H3-K36 specific) Biological Process: cell proliferation; DNA integration; histone H3-K4 methylation; DNA double-strand break processing; histone H3-K36 methylation; transposition, DNA-mediated; DNA catabolic process, endonucleolytic; double-strand break repair via nonhomologous end joining; replication fork processing |
| NCBI Summary: | This gene encodes a fusion protein that contains an N-terminal histone-lysine N-methyltransferase domain and a C-terminal mariner transposase domain. The encoded protein binds DNA and functions in DNA repair activities including non-homologous end joining and double strand break repair. The SET domain portion of this protein specifically methylates histone H3 lysines 4 and 36. This gene exists as a fusion gene only in anthropoid primates, other organisms lack mariner transposase domain. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013] |
| UniProt Code: | Q53H47 |
| NCBI GenInfo Identifier: | 613504379 |
| NCBI Gene ID: | 6419 |
| NCBI Accession: | Q53H47.2 |
| UniProt Related Accession: | Q53H47 |
| Molecular Weight: | 73kDa |
| NCBI Full Name: | Histone-lysine N-methyltransferase SETMAR |
| NCBI Synonym Full Names: | SET domain and mariner transposase fusion gene |
| NCBI Official Symbol: | SETMAR |
| NCBI Official Synonym Symbols: | Mar1; METNASE |
| NCBI Protein Information: | histone-lysine N-methyltransferase SETMAR |
| UniProt Protein Name: | Histone-lysine N-methyltransferase SETMAR |
| UniProt Synonym Protein Names: | SET domain and mariner transposase fusion protein; ; |
| Protein Family: | Histone-lysine N-methyltransferase |
| UniProt Gene Name: | SETMAR |
| UniProt Entry Name: | SETMR_HUMAN |
 | Immunofluorescence analysis of HeLa cells using SETMAR antibody (CAB6738). |
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