| UniProt Protein Function: | Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. |
| UniProt Code: | Q8WTS6 |
| NCBI GenInfo Identifier: | 25091217 |
| NCBI Gene ID: | 80854 |
| NCBI Accession: | Q8WTS6.1 |
| UniProt Secondary Accession: | Q8WTS6,Q0VAH3, Q4W5A9, Q9C0E6, B5WWL3, |
| UniProt Related Accession: | Q8WTS6 |
| Molecular Weight: | 40,721 Da |
| NCBI Full Name: | Histone-lysine N-methyltransferase SETD7 |
| NCBI Synonym Full Names: | SET domain containing lysine methyltransferase 7 |
| NCBI Official Symbol: | SETD7 |
| NCBI Official Synonym Symbols: | KMT7; SET7; SET9; SET7/9 |
| NCBI Protein Information: | histone-lysine N-methyltransferase SETD7 |
| UniProt Protein Name: | Histone-lysine N-methyltransferase SETD7 |
| UniProt Synonym Protein Names: | Histone H3-K4 methyltransferase SETD7; H3-K4-HMTase SETD7; Lysine N-methyltransferase 7; SET domain-containing protein 7; SET7/9 |
| Protein Family: | Histone-lysine N-methyltransferase |
| UniProt Gene Name: | SETD7 |
| UniProt Entry Name: | SETD7_HUMAN |
![Anti-SETD7 Antibody (CAB9985)[KO Validated]](https://cdn11.bigcommerce.com/s-39x6lpnvxv/images/stencil/590x590/products/26771/24960/anti-setd7-antibody-cab9985ko-validated__85425__49151.1644314082.jpg?c=1 "Anti-SETD7 Antibody (CAB9985)[KO Validated]")
