| UniProt Protein Function: | SETD1A: Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys- 9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overalpping localization with SETD1B suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. |
| UniProt Protein Details: | Protein type:Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; Methyltransferase; Methyltransferase, protein lysine Chromosomal Location of Human Ortholog: 16p11.2 Cellular Component: histone methyltransferase complex; nuclear chromatin; nuclear speck; nucleoplasm; nucleus Molecular Function:beta-catenin binding; histone lysine N-methyltransferase activity (H3-K4 specific); histone-lysine N-methyltransferase activity; protein binding; transcription factor binding |
| NCBI Summary: | The protein encoded by this gene is a component of a histone methyltransferase (HMT) complex that produces mono-, di-, and trimethylated histone H3 at Lys4. Trimethylation of histone H3 at lysine 4 (H3K4me3) is a chromatin modification known to generally mark the transcription start sites of active genes. The protein contains SET domains, a RNA recognition motif domain and is a member of the class V-like SAM-binding methyltransferase superfamily. [provided by RefSeq, Dec 2016] |
| UniProt Code: | O15047 |
| NCBI GenInfo Identifier: | 749385041 |
| NCBI Gene ID: | 9739 |
| NCBI Accession: | NM_014712.2 |
| UniProt Secondary Accession: | O15047,Q6PIF3, Q8TAJ6, A6NP62, |
| UniProt Related Accession: | O15047 |
| Molecular Weight: | ~61 kDa |
| NCBI Full Name: | Homo sapiens SET domain containing 1A (SETD1A), mRNA |
| NCBI Synonym Full Names: | SET domain containing 1A |
| NCBI Official Symbol: | SETD1A |
| NCBI Official Synonym Symbols: | Set1; KMT2F; Set1A |
| NCBI Protein Information: | histone-lysine N-methyltransferase SETD1A |
| UniProt Protein Name: | Histone-lysine N-methyltransferase SETD1A |
| UniProt Synonym Protein Names: | Lysine N-methyltransferase 2F; SET domain-containing protein 1A; hSET1A; Set1/Ash2 histone methyltransferase complex subunit SET1 |
| UniProt Gene Name: | SETD1A |
