Anti-SERPINI2 Antibody (CAB11732)
- SKU:
- CAB11732
- Product type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-SERPINI2 Antibody |
| Antibody SKU: | CAB11732 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 56-405 of human SERPINI2 (NP_006208.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse pancreas, Rat pancreas |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 56-405 of human SERPINI2 (NP_006208.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LEMV QLGA KGKA QQQI RQTL KQQE TSAG EEFF VLKS FFSA ISEK KQEF TFNL ANAL YLQE GFTV KEQY LHGN KEFF QSAI KLVD FQDA KACA EMIS TWVE RKTD GKIK DMFS GEEF GPLT RLVL VNAI YFKG DWKQ KFRK EDTQ LINF TKKN GSTV KIPM MKAL LRTK YGYF SESS LNYQ VLEL SYKG DEFS LIII LPAE GMDI EEVE KLIT AQQI LKWL SEMQ EEEV EISL PRFK VEQK VDFK DVLY SLNI TEIF SGGC DLSG ITDS SEVY VSQV TQKV FFEI NEDG SEAA TSTG IHIP VIMS LAQS QFIA NHPF LFIM KHNP TESI LFMG RVTN PDTQ EIKG RDLD SL |
| Gene ID: | 5276 |
| Uniprot: | O75830 |
| Cellular Location: | Secreted |
| Calculated MW: | 46kDa |
| Observed MW: | 46kDa |
| Synonyms: | SERPINI2, MEPI, PANCPIN, PI14, TSA2004, serpin I2 |
| Background: | The gene encodes a member of a family of proteins that acts as inhibitors of serine proteases. These proteins function in the regulation of a variety of physiological processes, including coagulation, fibrinolysis, development, malignancy, and inflammation. Expression of the encoded protein may be downregulated during pancreatic carcinogenesis. Alternative splicing results in multiple transcript variants for this gene. |
| UniProt Protein Function: | SERPINI2: is a member of the serine protease inhibitor (serpin) superfamily made up of proteins which play central roles in the regulation of a wide variety of physiological processes, including coagulation, fibrinolysis, development, malignancy and inflammation. The gene product may have a role in a growth-control, possibly growth-suppressing pathway and, when impaired, may be involved in pancreatic carcinogenesis. The protein is a member of the plasminogen activator inhibitor-1 family, a subset of the serpin superfamily whose members act as tissue-specific tPA inhibitors. Two alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 3q26.1 Cellular Component: extracellular space Molecular Function:protein binding Biological Process: cell motility |
| NCBI Summary: | The gene encodes a member of a family of proteins that acts as inhibitors of serine proteases. These proteins function in the regulation of a variety of physiological processes, including coagulation, fibrinolysis, development, malignancy, and inflammation. Expression of the encoded protein may be downregulated during pancreatic carcinogenesis. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013] |
| UniProt Code: | O75830 |
| NCBI GenInfo Identifier: | 20139983 |
| NCBI Gene ID: | 5276 |
| NCBI Accession: | O75830.1 |
| UniProt Related Accession: | O75830 |
| Molecular Weight: | 46,145 Da |
| NCBI Full Name: | Serpin I2 |
| NCBI Synonym Full Names: | serpin family I member 2 |
| NCBI Official Symbol: | SERPINI2 |
| NCBI Official Synonym Symbols: | MEPI; PI14; PANCPIN; TSA2004 |
| NCBI Protein Information: | serpin I2 |
| UniProt Protein Name: | Serpin I2 |
| UniProt Synonym Protein Names: | Myoepithelium-derived serine protease inhibitor; Pancpin; Pancreas-specific protein TSA2004; Peptidase inhibitor 14; PI-14 |
| Protein Family: | Serpin |
| UniProt Gene Name: | SERPINI2 |
| UniProt Entry Name: | SPI2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SERPINI2 antibody (CAB11732) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
 | Immunofluorescence analysis of rat pancreas using SERPINI2 Polyclonal Antibody (CAB11732) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of mouse pancreas using SERPINI2 Polyclonal Antibody (CAB11732) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
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