Anti-SERPINB9 Antibody (CAB6393)
- SKU:
- CAB6393
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-SERPINB9 Antibody |
| Antibody SKU: | CAB6393 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-376 of human SERPINB9 (NP_004146.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:10 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SW480, SKOV3, Mouse lung, Mouse spleen, Rat spleen, Rat thymus |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-376 of human SERPINB9 (NP_004146.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | METL SNAS GTFA IRLL KILC QDNP SHNV FCSP VSIS SALA MVLL GAKG NTAT QMAQ ALSL NTEE DIHR AFQS LLTE VNKA GTQY LLRT ANRL FGEK TCQF LSTF KESC LQFY HAEL KELS FIRA AEES RKHI NTWV SKKT EGKI EELL PGSS IDAE TRLV LVNA IYFK GKWN EPFD ETYT REMP FKIN QEEQ RPVQ MMYQ EATF KLAH VGEV RAQL LELP YARK ELSL LVLL PDDG VELS TVEK SLTF EKLT AWTK PDCM KSTE VEVL LPKF KLQE DYDM ESVL RHLG IVDA FQQG KADL SAMS AERD LCLS KFVH KSFV EVNE EGTE AAAA SSCF VVAE CCME SGPR FCAD HPFL FFIR HNRA NSIL FCGR FSSP |
| Gene ID: | 5272 |
| Uniprot: | P50453 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 42kDa |
| Observed MW: | 42kDa |
| Synonyms: | SERPINB9, CAP-3, CAP3, PI-9, PI9, serpin B9 |
| Background: | This gene encodes a member of the serine protease inhibitor family which are also known as serpins. The encoded protein belongs to a subfamily of intracellular serpins. This protein inhibits the activity of the effector molecule granzyme B. Overexpression of this protein may prevent cytotoxic T-lymphocytes from eliminating certain tumor cells. A pseudogene of this gene is found on chromosome 6. |
| UniProt Protein Function: | SERPINB9: Granzyme B inhibitor. Belongs to the serpin family. Ov-serpin subfamily. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 6p25 Cellular Component: extracellular space; membrane; cytoplasm; intracellular; nucleus; cytosol Molecular Function:serine-type endopeptidase inhibitor activity; protein binding; protease binding; caspase inhibitor activity Biological Process: mast cell mediated immunity; response to bacterium; immune response; negative regulation of caspase activity; negative regulation by symbiont of host apoptosis; protection from natural killer cell mediated cytotoxicity; negative regulation of apoptosis |
| NCBI Summary: | This gene encodes a member of the serine protease inhibitor family which are also known as serpins. The encoded protein belongs to a subfamily of intracellular serpins. This protein inhibits the activity of the effector molecule granzyme B. Overexpression of this protein may prevent cytotoxic T-lymphocytes from eliminating certain tumor cells. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Mar 2012] |
| UniProt Code: | P50453 |
| NCBI GenInfo Identifier: | 1709896 |
| NCBI Gene ID: | 5272 |
| NCBI Accession: | P50453.1 |
| UniProt Secondary Accession: | P50453,Q5TD03, B2RBW3, |
| UniProt Related Accession: | P50453 |
| Molecular Weight: | 376 |
| NCBI Full Name: | Serpin B9 |
| NCBI Synonym Full Names: | serpin peptidase inhibitor, clade B (ovalbumin), member 9 |
| NCBI Official Symbol: | SERPINB9 |
| NCBI Official Synonym Symbols: | PI9; CAP3; PI-9; CAP-3 |
| NCBI Protein Information: | serpin B9; peptidase inhibitor 9; cytoplasmic antiproteinase 3; protease inhibitor 9 (ovalbumin type); serpin peptidase inhibitor, clade B, member 9; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 9 |
| UniProt Protein Name: | Serpin B9 |
| UniProt Synonym Protein Names: | Cytoplasmic antiproteinase 3; CAP-3; CAP3; Peptidase inhibitor 9; PI-9 |
| Protein Family: | Serpin |
| UniProt Gene Name: | SERPINB9 |
| UniProt Entry Name: | SPB9_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SERPINB9 antibody (CAB6393) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunofluorescence analysis of C6 cells using SERPINB9 antibody (CAB6393) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of HeLa cells using SERPINB9 antibody (CAB6393) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of L929 cells using SERPINB9 antibody (CAB6393) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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