Anti-SERCA1/ATP2A1 Antibody (CAB19639)
- SKU:
- CAB19639
- Product type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- ATP2A
- SERCA1
Description
| Product Name: | SERCA1/ATP2A1 Rabbit mAb |
| Product Code: | CAB19639 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | ATP2A, SERCA1 |
| Applications: | WB, IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human SERCA1/ATP2A1 |
| Applications: | WB, IF |
| Recommended Dilutions: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse skeletal muscle |
| Immunogen: | A synthesized peptide derived from human SERCA1/ATP2A1 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 487 |
| Uniprot: | O14983 |
| Calculated MW: | 110kDa |
| Observed MW: | 110KDa |
| UniProt Protein Function: | ATP2A1: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction. Associated with sarcolipin (SLN) and phospholamban (PLN). Increased contractile activity leads to a decrease in SERCA1 expression, while decreased contractile activity leads to an increase in SERCA1 expression. Skeletal muscle, fast twitch muscle (type II) fibers. Reversibly inhibited by phospholamban (PLN) at low calcium concentrations. Dephosphorylated PLN decreases the apparent affinity of the ATPase for calcium. This inhibition is regulated by the phosphorylation of PLN. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transporter; Transporter, ion channel; Hydrolase; Membrane protein, multi-pass; Endoplasmic reticulum; Membrane protein, integral; EC 3.6.3.8 Chromosomal Location of Human Ortholog: 16p12.1 Cellular Component: I band; endoplasmic reticulum membrane; sarcoplasmic reticulum membrane; membrane; sarcoplasmic reticulum; perinuclear region of cytoplasm; ER-Golgi intermediate compartment; integral to membrane Molecular Function:protein binding; protein homodimerization activity; calcium-transporting ATPase activity; calcium ion binding; ATP binding Biological Process: apoptotic mitochondrial changes; metabolic process; positive regulation of fast-twitch skeletal muscle contraction; maintenance of mitochondrion localization; elevation of endoplasmic reticulum calcium ion concentration; reduction of endoplasmic reticulum calcium ion concentration; calcium ion transport; regulation of striated muscle contraction; blood coagulation; transmembrane transport; elevation of mitochondrial calcium ion concentration; negative regulation of striated muscle contraction Disease: Brody Myopathy |
| NCBI Summary: | This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in muscular excitation and contraction. Mutations in this gene cause some autosomal recessive forms of Brody disease, characterized by increasing impairment of muscular relaxation during exercise. Alternative splicing results in three transcript variants encoding different isoforms. [provided by RefSeq, Oct 2013] |
| UniProt Code: | O14983 |
| NCBI GenInfo Identifier: | 12643544 |
| NCBI Gene ID: | 487 |
| NCBI Accession: | O14983.1 |
| UniProt Secondary Accession: | O14983,O14984, A8K5J9, B3KY17, |
| UniProt Related Accession: | O14983 |
| Molecular Weight: | 95,199 Da |
| NCBI Full Name: | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 |
| NCBI Synonym Full Names: | ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 |
| NCBI Official Symbol: | ATP2A1 |
| NCBI Official Synonym Symbols: | ATP2A; SERCA1 |
| NCBI Protein Information: | sarcoplasmic/endoplasmic reticulum calcium ATPase 1; calcium pump 1; SR Ca(2+)-ATPase 1; endoplasmic reticulum class 1/2 Ca(2+) ATPase; calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform |
| UniProt Protein Name: | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 |
| UniProt Synonym Protein Names: | Calcium pump 1; Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform; Endoplasmic reticulum class 1/2 Ca(2+) ATPase |
| Protein Family: | Sarcoplasmic/endoplasmic reticulum calcium ATPase |
| UniProt Gene Name: | ATP2A1 |
| UniProt Entry Name: | AT2A1_HUMAN |
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