Anti-SEC24C 항체 (CAB10797)

Antibody Name:	Anti-SEC24C Antibody
Antibody SKU:	CAB10797
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 915-1094 of human SEC24C (NP_004913.2).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human
Positive Samples:	HeLa, HT-29, SKOV3

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 915-1094 of human SEC24C (NP_004913.2).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	DVLQ PGAE VTTD DRAY VRQL VTSM DVTE TNVF FYPR LLPL TKSP VEST TEPP AVRA SEER LSNG DIYL LENG LNLF LWVG ASVQ QGVV QSLF SVSS FSQI TSGL SVLP VLDN PLSK KVRG LIDS LRAQ RSRY MKLT VVKQ EDKM EMLF KHFL VEDK SLSG GASY VDFL CHMH KEIR QLLS
Gene ID:	9632
Uniprot:	P53992
Cellular Location:	Cytoplasm, Endoplasmic reticulum membrane, Golgi apparatus membrane, perinuclear region
Calculated MW:	38kDa/118kDa
Observed MW:	118kDa

Synonyms:

SEC24C

Background:

The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec24p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The product of this gene may play a role in shaping the vesicle, as well as in cargo selection and concentration. Alternatively spliced transcript variants encoding the same protein have been identified.

UniProt Protein Function:	SEC24C: Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex. Interacts with SLC6A4. COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and Sar1. SEC24C is capable of forming heterodimers with SEC24A. Interacts with TMED2 and TMED10. Ubiquitous. Belongs to the SEC23/SEC24 family. SEC24 subfamily.
UniProt Protein Details:	Protein type:Motor Chromosomal Location of Human Ortholog: 10q22.2 Cellular Component: cytosol; endoplasmic reticulum membrane Molecular Function:protein binding Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; antigen processing and presentation of peptide antigen via MHC class I; COPII coating of Golgi vesicle; ER to Golgi vesicle-mediated transport
NCBI Summary:	The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec24p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The product of this gene may play a role in shaping the vesicle, as well as in cargo selection and concentration. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
UniProt Code:	P53992
NCBI GenInfo Identifier:	257051070
NCBI Gene ID:	9632
NCBI Accession:	P53992.3
UniProt Secondary Accession:	P53992,Q8WV25, B4DZT4,
UniProt Related Accession:	P53992
Molecular Weight:	38,181 Da
NCBI Full Name:	Protein transport protein Sec24C
NCBI Synonym Full Names:	SEC24 homolog C, COPII coat complex component
NCBI Official Symbol:	SEC24C
NCBI Protein Information:	protein transport protein Sec24C
UniProt Protein Name:	Protein transport protein Sec24C
UniProt Synonym Protein Names:	SEC24-related protein C
Protein Family:	Protein transport protein
UniProt Gene Name:	SEC24C
UniProt Entry Name:	SC24C_HUMAN

Western blot analysis of extracts of various cell lines, using SEC24C antibody (CAB10797) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.

Antibodies

SEC24C Antibody (PACO12084)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)