Anti-SEC23B Antibody (CAB15131)
- SKU:
- CAB15131
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-SEC23B Antibody |
| Antibody SKU: | CAB15131 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 150-250 of human SEC23B (NP_006354.2). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, HepG2, Raji |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 150-250 of human SEC23B (NP_006354.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SLQM SLSL LPPD ALVG LITF GRMV QVHE LSCE GISK SYVF RGTK DLTA KQIQ DMLG LTKP AMPM QQAR PAQP QEHP FASS RFLQ PVHK IDMN LTDL LGEL Q |
| Gene ID: | 10483 |
| Uniprot: | Q15437 |
| Cellular Location: | Endoplasmic reticulum membrane, Endoplasmic reticulum-Golgi intermediate compartment membrane, Golgi apparatus membrane |
| Calculated MW: | 86kDa |
| Observed MW: | 86kDa |
| Synonyms: | SEC23B, CDA-II, CDAII, CDAN2, CWS7, HEMPAS |
| Background: | The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The function of this gene product has been implicated in cargo selection and concentration. Multiple alternatively spliced transcript variants have been identified in this gene. |
| UniProt Protein Function: | SEC23B: Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex. COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and Sar1. Belongs to the SEC23/SEC24 family. SEC23 subfamily. |
| UniProt Protein Details: | Protein type:Vesicle Chromosomal Location of Human Ortholog: 20p11.23 Cellular Component: endomembrane system; intracellular membrane-bound organelle; membrane Molecular Function:protein binding Biological Process: vesicle-mediated transport Disease: Anemia, Congenital Dyserythropoietic, Type Ii |
| NCBI Summary: | The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The function of this gene product has been implicated in cargo selection and concentration. Multiple alternatively spliced transcript variants have been identified in this gene. [provided by RefSeq, Feb 2010] |
| UniProt Code: | Q15437 |
| NCBI GenInfo Identifier: | 20141794 |
| NCBI Gene ID: | 10483 |
| NCBI Accession: | Q15437.2 |
| UniProt Secondary Accession: | Q15437,Q503A9, Q5W183, Q9BS15, Q9BSI2, Q9H1D7, D3DW33 |
| UniProt Related Accession: | Q15437 |
| Molecular Weight: | 86,479 Da |
| NCBI Full Name: | Protein transport protein Sec23B |
| NCBI Synonym Full Names: | Sec23 homolog B, coat complex II component |
| NCBI Official Symbol: | SEC23B |
| NCBI Official Synonym Symbols: | CWS7; CDAII; CDAN2; CDA-II; HEMPAS |
| NCBI Protein Information: | protein transport protein Sec23B |
| UniProt Protein Name: | Protein transport protein Sec23B |
| UniProt Synonym Protein Names: | SEC23-related protein B |
| Protein Family: | Protein transport protein |
| UniProt Gene Name: | SEC23B |
| UniProt Entry Name: | SC23B_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SEC23B antibody (CAB15131) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunofluorescence analysis of C6 cells using SEC23B antibody (CAB15131) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of L929 cells using SEC23B antibody (CAB15131) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of U-2 OS cells using SEC23B antibody (CAB15131) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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