Anti-SEC23A Antibody (CAB12101)
- SKU:
- CAB12101
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-SEC23A Antibody |
| Antibody SKU: | CAB12101 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human SEC23A (NP_006355.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | B cells, LO2, HeLa, SGC-7901, HT-29, Mouse brain, Mouse liver, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human SEC23A (NP_006355.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MTTY LEFI QQNE ERDG VRFS WNVW PSSR LEAT RMVV PVAA LFTP LKER PDLP PIQY EPVL CSRT TCRA VLNP LCQV DYRA KLWA CNFC YQRN QFPP SYAG ISEL NQPA ELLP QFSS IEYV VLRG PQMP LIFL YVVD TCME DEDL QALK ES |
| Gene ID: | 10484 |
| Uniprot: | Q15436 |
| Cellular Location: | Golgi apparatus membrane, Peripheral membrane protein, Smooth endoplasmic reticulum membrane |
| Calculated MW: | 63kDa/86kDa |
| Observed MW: | 86kDa |
| Synonyms: | SEC23A, CLSD |
| Background: | The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family. It is part of a protein complex and found in the ribosome-free transitional face of the endoplasmic reticulum (ER) and associated vesicles. This protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The encoded protein is suggested to play a role in the ER-Golgi protein trafficking. |
| UniProt Protein Function: | SEC23A: Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex. COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and Sar1. Interacts with SEC23IP. Interacts with HTR4. Interacts with SLC6A4. Interacts with SEC16A. Belongs to the SEC23/SEC24 family. SEC23 subfamily. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 14q21.1 Cellular Component: COPII vesicle coat; cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; Golgi membrane; perinuclear region of cytoplasm; smooth endoplasmic reticulum membrane Molecular Function:protein binding; zinc ion binding Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; antigen processing and presentation of peptide antigen via MHC class I; COPII coating of Golgi vesicle; ER to Golgi vesicle-mediated transport; intracellular protein transport; vesicle-mediated transport Disease: Craniolenticulosutural Dysplasia |
| NCBI Summary: | The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family. It is part of a protein complex and found in the ribosome-free transitional face of the endoplasmic reticulum (ER) and associated vesicles. This protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The encoded protein is suggested to play a role in the ER-Golgi protein trafficking. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q15436 |
| NCBI GenInfo Identifier: | 143811354 |
| NCBI Gene ID: | 10484 |
| NCBI Accession: | Q15436.2 |
| UniProt Secondary Accession: | Q15436,Q8NE16, B2R5P4, B3KXI2, |
| UniProt Related Accession: | Q15436 |
| Molecular Weight: | 63,101 Da |
| NCBI Full Name: | Protein transport protein Sec23A |
| NCBI Synonym Full Names: | Sec23 homolog A, coat complex II component |
| NCBI Official Symbol: | SEC23A |
| NCBI Official Synonym Symbols: | CLSD |
| NCBI Protein Information: | protein transport protein Sec23A |
| UniProt Protein Name: | Protein transport protein Sec23A |
| UniProt Synonym Protein Names: | SEC23-related protein A |
| Protein Family: | SEC23-interacting protein |
| UniProt Gene Name: | SEC23A |
| UniProt Entry Name: | SC23A_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SEC23A antibody (CAB12101) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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