Anti-SCGB3A2 Antibody (CAB13137)
- SKU:
- CAB13137
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-SCGB3A2 Antibody |
| Antibody SKU: | CAB13137 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-93 of human SCGB3A2 (NP_473364.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A-549, Raji, mouse lung, rat lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-93 of human SCGB3A2 (NP_473364.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MKLV TIFL LVTI SLCS YSAT AFLI NKVP LPVD KLAP LPLD NILP FMDP LKLL LKTL GISV EHLV EGLR KCVN ELGP EASE AVKK LLEA LSHL V |
| Gene ID: | 117156 |
| Uniprot: | Q96PL1 |
| Cellular Location: | Secreted |
| Calculated MW: | 10kDa |
| Observed MW: | 14kDa |
| Synonyms: | SCGB3A2, LU103, PNSP1, UGRP1, pnSP-1 |
| Background: | The protein encoded by this gene is a secreted lung surfactant protein and a downstream target of thyroid transcription factor. A single nucleotide polymorphism in the promoter of this gene results in susceptibility to asthma. |
| UniProt Protein Function: | Secreted cytokine-like protein (PubMed:12847263). Binds to the scavenger receptor MARCO (PubMed:12847263). Can also bind to pathogens including the Gram-positive bacterium L.monocytogenes, the Gram-negative bacterium P.aeruginosa, and yeast (PubMed:12847263). Strongly inhibits phospholipase A2 (PLA2G1B) activity (PubMed:24213919). Seems to have anti-inflammatory effects in respiratory epithelium. Also has anti-fibrotic activity in lung (PubMed:24213919). May play a role in fetal lung development and maturation (PubMed:24213919). Promotes branching morphogenesis during early stages of lung development (PubMed:24213919). In the pituitary, may inhibit production of follicle-stimulating hormone (FSH) and luteinizing hormone (LH). |
| NCBI Summary: | The protein encoded by this gene is a secreted lung surfactant protein and a downstream target of thyroid transcription factor. A single nucleotide polymorphism in the promoter of this gene results in susceptibility to asthma.[provided by RefSeq, Mar 2010] |
| UniProt Code: | Q96PL1 |
| NCBI GenInfo Identifier: | 16876445 |
| NCBI Gene ID: | 117156 |
| NCBI Accession: | NP_473364.1 |
| UniProt Related Accession: | Q96PL1 |
| Molecular Weight: | Molecular Mass: 7.9 kDaActual Protein Molecular Mass: 7 kDa |
| NCBI Full Name: | secretoglobin family 3A member 2 |
| NCBI Synonym Full Names: | secretoglobin family 3A member 2 |
| NCBI Official Symbol: | SCGB3A2 |
| NCBI Official Synonym Symbols: | LU103; PNSP1; UGRP1; pnSP-1 |
| NCBI Protein Information: | secretoglobin family 3A member 2 |
| UniProt Protein Name: | Secretoglobin family 3A member 2 |
| UniProt Synonym Protein Names: | Pneumo secretory protein 1; PnSP-1; Uteroglobin-related protein 1 |
| UniProt Gene Name: | SCGB3A2 |
 | Western blot analysis of extracts of various cell lines, using SCGB3A2 antibody (CAB13137) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
 | Immunofluorescence analysis of C6 cells using SCGB3A2 antibody (CAB13137) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of L929 cells using SCGB3A2 antibody (CAB13137) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of U-2 OS cells using SCGB3A2 antibody (CAB13137) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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